Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Achim Hoerauf; Sabine Specht; Marcelle Büttner; Kenneth Pfarr; Sabine Mand; Rolf Fimmers; Yeboah Marfo-Debrekyei; Peter Konadu; Alexander Yaw Debrah; Claudio Bandi; Norbert Brattig; Anna Albers; John Larbi; Linda Batsa; Mark Taylor; Ohene Adjei; Dietrich W. Büttner

doi:10.1007/s00430-007-0072-z

Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Achim Hoerauf, Sabine Specht, Marcelle Büttner, Kenneth Pfarr, Sabine Mand, Rolf Fimmers, Yeboah Marfo-Debrekyei, Peter Konadu, Alexander Yaw Debrah, Claudio Bandi, Norbert Brattig, Anna Albers, John Larbi, Linda Batsa, Mark Taylor, Ohene Adjei, Dietrich W. Büttner

Tropical Disease Biology

Research output: Other contribution

3 Citations (Scopus)

Abstract

In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60% of the female worms found dead, despite the presence of new, Wolbachia-containing worms acquired after the administration of doxycycline. Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections.

Original language	English
Number of pages	1
Edition	3
Volume	197
DOIs	https://doi.org/10.1007/s00430-007-0072-z
Publication status	Published - 1 Sept 2008

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Name	Medical Microbiology and Immunology

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10.1007/s00430-007-0072-z

3 Citations
1 Article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: A randomized placebo-controlled study: A randomized placebo-controlled study
Hoerauf, A., Specht, S., Büttner, M., Pfarr, K., Mand, S., Fimmers, R., Marfo-Debrekyei, Y., Konadu, P., Debrah, A. Y., Bandi, C., Brattig, N., Albers, A., Larbi, J., Batsa, L., Taylor, M., Adjei, O. & Büttner, D. W., 1 Sept 2008, In: Medical Microbiology and Immunology. 197, 3, p. 295-311 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
219 Citations (Scopus)

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Hoerauf, A., Specht, S., Büttner, M., Pfarr, K., Mand, S., Fimmers, R., Marfo-Debrekyei, Y., Konadu, P., Debrah, A. Y., Bandi, C., Brattig, N., Albers, A., Larbi, J., Batsa, L., Taylor, M., Adjei, O., & Büttner, D. W. (2008, Sept 1). Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. (3 ed.) https://doi.org/10.1007/s00430-007-0072-z

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title = "Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study",

abstract = "In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60\% of the female worms found dead, despite the presence of new, Wolbachia-containing worms acquired after the administration of doxycycline. Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections.",

author = "Achim Hoerauf and Sabine Specht and Marcelle B{\"u}ttner and Kenneth Pfarr and Sabine Mand and Rolf Fimmers and Yeboah Marfo-Debrekyei and Peter Konadu and Debrah, \{Alexander Yaw\} and Claudio Bandi and Norbert Brattig and Anna Albers and John Larbi and Linda Batsa and Mark Taylor and Ohene Adjei and B{\"u}ttner, \{Dietrich W.\}",

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Hoerauf, A, Specht, S, Büttner, M, Pfarr, K, Mand, S, Fimmers, R, Marfo-Debrekyei, Y, Konadu, P, Debrah, AY, Bandi, C, Brattig, N, Albers, A, Larbi, J, Batsa, L, Taylor, M, Adjei, O & Büttner, DW 2008, Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. https://doi.org/10.1007/s00430-007-0072-z

TY - GEN

T1 - Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

AU - Hoerauf, Achim

AU - Specht, Sabine

AU - Büttner, Marcelle

AU - Pfarr, Kenneth

AU - Mand, Sabine

AU - Fimmers, Rolf

AU - Marfo-Debrekyei, Yeboah

AU - Konadu, Peter

AU - Debrah, Alexander Yaw

AU - Bandi, Claudio

AU - Brattig, Norbert

AU - Albers, Anna

AU - Larbi, John

AU - Batsa, Linda

AU - Taylor, Mark

AU - Adjei, Ohene

AU - Büttner, Dietrich W.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60% of the female worms found dead, despite the presence of new, Wolbachia-containing worms acquired after the administration of doxycycline. Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections.

AB - In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60% of the female worms found dead, despite the presence of new, Wolbachia-containing worms acquired after the administration of doxycycline. Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections.

U2 - 10.1007/s00430-007-0072-z

DO - 10.1007/s00430-007-0072-z

M3 - Other contribution

VL - 197

T3 - Medical Microbiology and Immunology

ER -

Erratum: Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

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Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: A randomized placebo-controlled study: A randomized placebo-controlled study

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