Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.

Matthew J. Kelly; Laura A. Benjamin; Katharine Cartwright; Katherine M.B. Ajdukiewicz; Danielle B. Cohen; Mavis Menyere; Sareen Galbraith; Malcolm Guiver; Florian Neuhann; Tom Solomon; David Lalloo; Robert S. Heyderman

doi:10.1093/infdis/jir707

Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.

Matthew J. Kelly, Laura A. Benjamin, Katharine Cartwright, Katherine M.B. Ajdukiewicz, Danielle B. Cohen, Mavis Menyere, Sareen Galbraith, Malcolm Guiver, Florian Neuhann, Tom Solomon, David Lalloo, Robert S. Heyderman

Clinical Sciences

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Abstract

Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.

Original language	English
Pages (from-to)	106-110
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	205
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jir707
Publication status	Published - 1 Jan 2012

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Epstein-Barr Virus Coinfection in Cerebrospinal fluidFinal published version, 156 KBLicence: CC BY-NC

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Kelly, M. J., Benjamin, L. A., Cartwright, K., Ajdukiewicz, K. M. B., Cohen, D. B., Menyere, M., Galbraith, S., Guiver, M., Neuhann, F., Solomon, T., Lalloo, D., & Heyderman, R. S. (2012). Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis. Journal of Infectious Diseases, 205(1), 106-110. https://doi.org/10.1093/infdis/jir707

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title = "Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.",

abstract = "Mortality from adult bacterial meningitis exceeds 50\% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54\%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.",

author = "Kelly, \{Matthew J.\} and Benjamin, \{Laura A.\} and Katharine Cartwright and Ajdukiewicz, \{Katherine M.B.\} and Cohen, \{Danielle B.\} and Mavis Menyere and Sareen Galbraith and Malcolm Guiver and Florian Neuhann and Tom Solomon and David Lalloo and Heyderman, \{Robert S.\}",

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Kelly, MJ, Benjamin, LA, Cartwright, K, Ajdukiewicz, KMB, Cohen, DB, Menyere, M, Galbraith, S, Guiver, M, Neuhann, F, Solomon, T, Lalloo, D & Heyderman, RS 2012, 'Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.', Journal of Infectious Diseases, vol. 205, no. 1, pp. 106-110. https://doi.org/10.1093/infdis/jir707

TY - JOUR

T1 - Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.

AU - Kelly, Matthew J.

AU - Benjamin, Laura A.

AU - Cartwright, Katharine

AU - Ajdukiewicz, Katherine M.B.

AU - Cohen, Danielle B.

AU - Menyere, Mavis

AU - Galbraith, Sareen

AU - Guiver, Malcolm

AU - Neuhann, Florian

AU - Solomon, Tom

AU - Lalloo, David

AU - Heyderman, Robert S.

PY - 2012/1/1

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N2 - Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.

AB - Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.

U2 - 10.1093/infdis/jir707

DO - 10.1093/infdis/jir707

M3 - Article

SN - 0022-1899

VL - 205

SP - 106

EP - 110

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 1

ER -

Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.

Abstract

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