EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis

Comella-del-Barrio; JL Izquierdo-Garcia; Muriel Moreno; E García-García; P Millet; I Molina-Pinargote; C Prat-Aymerich; J Ruiz-Cabello; Luis Cuevas; J Domínguez

EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis

Comella-del-Barrio, JL Izquierdo-Garcia, Muriel Moreno, E García-García, P Millet, I Molina-Pinargote, C Prat-Aymerich, J Ruiz-Cabello, Luis Cuevas, J Domínguez

Clinical Sciences

Research output: Contribution to conference › Paper

Abstract

The emergence of drug-resistant tuberculosis (TB) challenges the control of TB with an increase in treatment failure. Surveillance during treatment is essential to monitor adherence and treatment response.

Metabolomics can be used to obtain a "fingerprint" of the metabolites presents in a biological sample, allowing the study of sets of metabolites affected by host-pathogen interactions and the identification of therapeutic markers to improve the evaluation of the TB outcome.

In this proof of concept, we aimed to characterize the urinary metabolic profile of patients receiving anti-TB treatment and its association to TB treatment outcome.

Original language	English
Pages	S200
Publication status	Published - 23 Oct 2020

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Comella-del-Barrio, Izquierdo-Garcia, JL., Muriel Moreno, García-García, E., Millet, P., Molina-Pinargote, I., Prat-Aymerich, C., Ruiz-Cabello, J., Cuevas, L., & Domínguez, J. (2020). EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis. S200. https://conf2020.theunion.org/wp-content/uploads/2020/10/WCLH2020_abstract_book_high.pdf

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abstract = "The emergence of drug-resistant tuberculosis (TB) challenges the control of TB with an increase in treatment failure. Surveillance during treatment is essential to monitor adherence and treatment response.Metabolomics can be used to obtain a {"}fingerprint{"} of the metabolites presents in a biological sample, allowing the study of sets of metabolites affected by host-pathogen interactions and the identification of therapeutic markers to improve the evaluation of the TB outcome.In this proof of concept, we aimed to characterize the urinary metabolic profile of patients receiving anti-TB treatment and its association to TB treatment outcome.",

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Comella-del-Barrio, Izquierdo-Garcia, JL, Muriel Moreno, García-García, E, Millet, P, Molina-Pinargote, I, Prat-Aymerich, C, Ruiz-Cabello, J, Cuevas, L & Domínguez, J 2020, 'EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis', pp. S200. <https://conf2020.theunion.org/wp-content/uploads/2020/10/WCLH2020_abstract_book_high.pdf>

TY - CONF

T1 - EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis

AU - Comella-del-Barrio, null

AU - Izquierdo-Garcia, JL

AU - Muriel Moreno, null

AU - García-García, E

AU - Millet, P

AU - Molina-Pinargote, I

AU - Prat-Aymerich, C

AU - Ruiz-Cabello, J

AU - Cuevas, Luis

AU - Domínguez, J

PY - 2020/10/23

Y1 - 2020/10/23

N2 - The emergence of drug-resistant tuberculosis (TB) challenges the control of TB with an increase in treatment failure. Surveillance during treatment is essential to monitor adherence and treatment response.Metabolomics can be used to obtain a "fingerprint" of the metabolites presents in a biological sample, allowing the study of sets of metabolites affected by host-pathogen interactions and the identification of therapeutic markers to improve the evaluation of the TB outcome.In this proof of concept, we aimed to characterize the urinary metabolic profile of patients receiving anti-TB treatment and its association to TB treatment outcome.

AB - The emergence of drug-resistant tuberculosis (TB) challenges the control of TB with an increase in treatment failure. Surveillance during treatment is essential to monitor adherence and treatment response.Metabolomics can be used to obtain a "fingerprint" of the metabolites presents in a biological sample, allowing the study of sets of metabolites affected by host-pathogen interactions and the identification of therapeutic markers to improve the evaluation of the TB outcome.In this proof of concept, we aimed to characterize the urinary metabolic profile of patients receiving anti-TB treatment and its association to TB treatment outcome.

M3 - Paper

SP - S200

ER -

EP27-355-23 Characterization of the metabolic urine profile using nuclear magnetic resonance (NMR) spectroscopy to monitor treatment of tuberculosis

Abstract

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