Elevated plasma von Willebrand factor and propeptide levels in malawian children with malaria.

Happy T. Phiri; Daniel J. Bridges; Simon J. Glover; Jan A. van Mourik; Bas de Laat; Bridon M'baya; Terrie E. Taylor; Karl B. Seydel; Malcolm E. Molyneux; E. Brian Faragher; Alister Craig; James E.G. Bunn

doi:10.1371/journal.pone.0025626

Elevated plasma von Willebrand factor and propeptide levels in malawian children with malaria.

Happy T. Phiri
, Daniel J. Bridges
, Simon J. Glover
, Jan A. van Mourik
, Bas de Laat
, Bridon M'baya
, Terrie E. Taylor
, Karl B. Seydel
, Malcolm E. Molyneux
, E. Brian Faragher
, Alister Craig
, James E.G. Bunn

Biological Sciences

University of Malawi
Departments of Plasma Proteins and Blood Coagulation
Malawi Blood Transfusion Service
Michigan State University
Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

In children with malaria plasma VWF and propeptide levels are markedly elevated in both cerebral and mild paediatric malaria, with levels matching disease severity, and these normalize upon recovery. High levels of both markers also occur in retinopathy-negative 'cerebral malaria' cases, many of whom are thought to be suffering from diseases other than malaria, indicating that further studies of these markers will be required to determine their sensitivity and specificity.

Original language	English
Article number	e25626
Pages (from-to)	e25626
Journal	PLoS ONE
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0025626
Publication status	Published - 17 Nov 2011

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SDG 3 Good Health and Well-being

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Plos ONE 6 11 e25626Final published version, 295 KBLicence: CC BY

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title = "Elevated plasma von Willebrand factor and propeptide levels in malawian children with malaria.",

abstract = "In children with malaria plasma VWF and propeptide levels are markedly elevated in both cerebral and mild paediatric malaria, with levels matching disease severity, and these normalize upon recovery. High levels of both markers also occur in retinopathy-negative 'cerebral malaria' cases, many of whom are thought to be suffering from diseases other than malaria, indicating that further studies of these markers will be required to determine their sensitivity and specificity.",

author = "Phiri, \{Happy T.\} and Bridges, \{Daniel J.\} and Glover, \{Simon J.\} and \{van Mourik\}, \{Jan A.\} and \{de Laat\}, Bas and Bridon M'baya and Taylor, \{Terrie E.\} and Seydel, \{Karl B.\} and Molyneux, \{Malcolm E.\} and Faragher, \{E. Brian\} and Alister Craig and Bunn, \{James E.G.\}",

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T1 - Elevated plasma von Willebrand factor and propeptide levels in malawian children with malaria.

AU - Phiri, Happy T.

AU - Bridges, Daniel J.

AU - Glover, Simon J.

AU - van Mourik, Jan A.

AU - de Laat, Bas

AU - M'baya, Bridon

AU - Taylor, Terrie E.

AU - Seydel, Karl B.

AU - Molyneux, Malcolm E.

AU - Faragher, E. Brian

AU - Craig, Alister

AU - Bunn, James E.G.

PY - 2011/11/17

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N2 - In children with malaria plasma VWF and propeptide levels are markedly elevated in both cerebral and mild paediatric malaria, with levels matching disease severity, and these normalize upon recovery. High levels of both markers also occur in retinopathy-negative 'cerebral malaria' cases, many of whom are thought to be suffering from diseases other than malaria, indicating that further studies of these markers will be required to determine their sensitivity and specificity.

AB - In children with malaria plasma VWF and propeptide levels are markedly elevated in both cerebral and mild paediatric malaria, with levels matching disease severity, and these normalize upon recovery. High levels of both markers also occur in retinopathy-negative 'cerebral malaria' cases, many of whom are thought to be suffering from diseases other than malaria, indicating that further studies of these markers will be required to determine their sensitivity and specificity.

U2 - 10.1371/journal.pone.0025626

DO - 10.1371/journal.pone.0025626

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SP - e25626

JO - PLoS ONE

JF - PLoS ONE

IS - 11

M1 - e25626

ER -

Elevated plasma von Willebrand factor and propeptide levels in malawian children with malaria.

Abstract

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