Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Naomi Walker; F. Karim; M. Y.S. Moosa; S. Moodley; M. Mazibuko; K. Khan; T. R. Sterling; Y. F. Van Der Heijden; A. D. Grant; P. T. Elkington; A. Pym; A. Leslie

doi:10.1093/infdis/jiac160

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Naomi Walker, F. Karim, M. Y.S. Moosa, S. Moodley, M. Mazibuko, K. Khan, T. R. Sterling, Y. F. Van Der Heijden, A. D. Grant, P. T. Elkington, A. Pym, A. Leslie

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.

Original language	English
Pages (from-to)	928-932
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	226
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jiac160
Publication status	Published - 1 May 2022

Keywords

diagnosis
HIV
immunopathology
matrix metalloproteinase
procollagen III N-terminal propeptide
Tuberculosis

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JID 2022 Walker et al MMP-8 cult posFinal published version, 435 KBLicence: CC BY

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Walker, N., Karim, F., Moosa, M. Y. S., Moodley, S., Mazibuko, M., Khan, K., Sterling, T. R., Van Der Heijden, Y. F., Grant, A. D., Elkington, P. T., Pym, A., & Leslie, A. (2022). Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis. Journal of Infectious Diseases, 226(5), 928-932. https://doi.org/10.1093/infdis/jiac160

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abstract = "Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.",

keywords = "diagnosis, HIV, immunopathology, matrix metalloproteinase, procollagen III N-terminal propeptide, Tuberculosis",

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doi = "10.1093/infdis/jiac160",

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AU - Walker, Naomi

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AU - Moosa, M. Y.S.

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AU - Mazibuko, M.

AU - Khan, K.

AU - Sterling, T. R.

AU - Van Der Heijden, Y. F.

AU - Grant, A. D.

AU - Elkington, P. T.

AU - Pym, A.

AU - Leslie, A.

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AB - Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.

KW - diagnosis

KW - HIV

KW - immunopathology

KW - matrix metalloproteinase

KW - procollagen III N-terminal propeptide

KW - Tuberculosis

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DO - 10.1093/infdis/jiac160

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Abstract

Keywords

UN SDGs

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