Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Naomi Walker; F. Karim; M. Y.S. Moosa; S. Moodley; M. Mazibuko; K. Khan; T. R. Sterling; Y. F. Van Der Heijden; A. D. Grant; P. T. Elkington; A. Pym; A. Leslie

doi:10.1093/infdis/jiac160

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Naomi Walker
, F. Karim
, M. Y.S. Moosa
, S. Moodley
, M. Mazibuko
, K. Khan
, T. R. Sterling
, Y. F. Van Der Heijden
, A. D. Grant
, P. T. Elkington
, A. Pym
, A. Leslie

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.

Original language	English
Pages (from-to)	928-932
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	226
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jiac160
Publication status	Published - 1 May 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diagnosis
HIV
immunopathology
matrix metalloproteinase
procollagen III N-terminal propeptide
Tuberculosis

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10.1093/infdis/jiac160Licence: CC BY

JID 2022 Walker et al MMP-8 cult posFinal published version, 435 KBLicence: CC BY

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Walker, N., Karim, F., Moosa, M. Y. S., Moodley, S., Mazibuko, M., Khan, K., Sterling, T. R., Van Der Heijden, Y. F., Grant, A. D., Elkington, P. T., Pym, A., & Leslie, A. (2022). Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis. Journal of Infectious Diseases, 226(5), 928-932. https://doi.org/10.1093/infdis/jiac160

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title = "Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis",

abstract = "Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.",

keywords = "diagnosis, HIV, immunopathology, matrix metalloproteinase, procollagen III N-terminal propeptide, Tuberculosis",

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AU - Moodley, S.

AU - Mazibuko, M.

AU - Khan, K.

AU - Sterling, T. R.

AU - Van Der Heijden, Y. F.

AU - Grant, A. D.

AU - Elkington, P. T.

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AU - Leslie, A.

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AB - Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.

KW - diagnosis

KW - HIV

KW - immunopathology

KW - matrix metalloproteinase

KW - procollagen III N-terminal propeptide

KW - Tuberculosis

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JF - Journal of Infectious Diseases

IS - 5

ER -

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Abstract

UN SDGs

Keywords

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