Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N. Newton; Steve Ward; Brian J. Angus; Wirongrong Chierakul; Arjen Dondorp; Ronnatrai Ruangveerayuth; Kamolrat Silamut; Pramote Teerapong; Yupin Suputtamongkol; Sornchai Looareesuwan; Nicholas J. White

doi:10.1016/j.trstmh.2005.01.008

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N. Newton
, Steve Ward
, Brian J. Angus
, Wirongrong Chierakul
, Arjen Dondorp
, Ronnatrai Ruangveerayuth
, Kamolrat Silamut
, Pramote Teerapong
, Yupin Suputtamongkol
, Sornchai Looareesuwan
, Nicholas J. White

Tropical Disease Biology

Mahidol University
Oxford University Hospitals NHS Foundation Trust
Mae Sot Hospital

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	184-186
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/j.trstmh.2005.01.008
Publication status	Published - 1 Feb 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Malaria
Pharmacokinetics
Plasmodium falciparum
Quinine
Thailand
Treatment failure

Access to Document

10.1016/j.trstmh.2005.01.008

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Newton, P. N., Ward, S., Angus, B. J., Chierakul, W., Dondorp, A., Ruangveerayuth, R., Silamut, K., Teerapong, P., Suputtamongkol, Y., Looareesuwan, S., & White, N. J. (2006). Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(2), 184-186. https://doi.org/10.1016/j.trstmh.2005.01.008

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title = "Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations",

abstract = "A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.",

keywords = "Malaria, Pharmacokinetics, Plasmodium falciparum, Quinine, Thailand, Treatment failure",

author = "Newton, \{Paul N.\} and Steve Ward and Angus, \{Brian J.\} and Wirongrong Chierakul and Arjen Dondorp and Ronnatrai Ruangveerayuth and Kamolrat Silamut and Pramote Teerapong and Yupin Suputtamongkol and Sornchai Looareesuwan and White, \{Nicholas J.\}",

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doi = "10.1016/j.trstmh.2005.01.008",

language = "English",

volume = "100",

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Newton, PN, Ward, S, Angus, BJ, Chierakul, W, Dondorp, A, Ruangveerayuth, R, Silamut, K, Teerapong, P, Suputtamongkol, Y, Looareesuwan, S & White, NJ 2006, 'Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 2, pp. 184-186. https://doi.org/10.1016/j.trstmh.2005.01.008

TY - JOUR

T1 - Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

AU - Newton, Paul N.

AU - Ward, Steve

AU - Angus, Brian J.

AU - Chierakul, Wirongrong

AU - Dondorp, Arjen

AU - Ruangveerayuth, Ronnatrai

AU - Silamut, Kamolrat

AU - Teerapong, Pramote

AU - Suputtamongkol, Yupin

AU - Looareesuwan, Sornchai

AU - White, Nicholas J.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

AB - A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

KW - Malaria

KW - Pharmacokinetics

KW - Plasmodium falciparum

KW - Quinine

KW - Thailand

KW - Treatment failure

U2 - 10.1016/j.trstmh.2005.01.008

DO - 10.1016/j.trstmh.2005.01.008

M3 - Article

SN - 0035-9203

VL - 100

SP - 184

EP - 186

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 2

ER -

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Abstract

UN SDGs

Keywords

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