Early anti-HBs antibody response to accelerated and to conventional hepatitis B vaccination regimens in healthy persons

A. D. Harries; M. Clark; Nicholas Beeching; J. Lavelle; K. J. Mutton

doi:10.1016/0163-4453(91)92792-4

Early anti-HBs antibody response to accelerated and to conventional hepatitis B vaccination regimens in healthy persons

A. D. Harries, M. Clark, Nicholas Beeching, J. Lavelle, K. J. Mutton

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60 % students at 1 month and 27 % at 2 months were still unprotected (anti-HBs titre < 10·0 IU/1). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	Journal of Infection
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/0163-4453(91)92792-4
Publication status	Published - 1 Nov 1991
Externally published	Yes

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10.1016/0163-4453(91)92792-4

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abstract = "A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60 \% students at 1 month and 27 \% at 2 months were still unprotected (anti-HBs titre < 10·0 IU/1). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.",

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AU - Harries, A. D.

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AU - Beeching, Nicholas

AU - Lavelle, J.

AU - Mutton, K. J.

PY - 1991/11/1

Y1 - 1991/11/1

N2 - A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60 % students at 1 month and 27 % at 2 months were still unprotected (anti-HBs titre < 10·0 IU/1). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.

AB - A significantly higher prevalence of a protective concentration of anti-HBs was achieved at 1 and 2 months among 132 healthy medical students who received an accelerated vaccination schedule with a recombinant hepatitis B vaccine (Engerix-B) than among 120 medical students who received a conventional regimen. With the accelerated schedule, however, 60 % students at 1 month and 27 % at 2 months were still unprotected (anti-HBs titre < 10·0 IU/1). Additional passive immunisation should therefore continue to be offered if the accelerated schedule is adopted for post-exposure prophylaxis.

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DO - 10.1016/0163-4453(91)92792-4

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EP - 254

JO - Journal of Infection

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Early anti-HBs antibody response to accelerated and to conventional hepatitis B vaccination regimens in healthy persons

Abstract

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