Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Thomas P.C. Dorlo; Pieter P.A.M. van Thiel; Gerard J. Schoone; Ymkje Stienstra; Michèle van Vugt; Jos H. Beijnen; Peter J. de Vries

doi:10.1371/journal.pntd.0001436

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Thomas P.C. Dorlo, Pieter P.A.M. van Thiel, Gerard J. Schoone, Ymkje Stienstra, Michèle van Vugt, Jos H. Beijnen, Peter J. de Vries

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Abstract

Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ~1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.

Original language	English
Article number	e1436
Journal	PLoS Neglected Tropical Diseases
Volume	5
Issue number	12
DOIs	https://doi.org/10.1371/journal.pntd.0001436
Publication status	Published - 1 Dec 2011
Externally published	Yes

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title = "Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine",

abstract = "Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of \textasciitilde{}1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.",

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AU - Dorlo, Thomas P.C.

AU - van Thiel, Pieter P.A.M.

AU - Schoone, Gerard J.

AU - Stienstra, Ymkje

AU - van Vugt, Michèle

AU - Beijnen, Jos H.

AU - de Vries, Peter J.

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AB - Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ~1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.

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Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Abstract

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