Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Thomas P.C. Dorlo; Pieter P.A.M. van Thiel; Gerard J. Schoone; Ymkje Stienstra; Michèle van Vugt; Jos H. Beijnen; Peter J. de Vries

doi:10.1371/journal.pntd.0001436

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Thomas P.C. Dorlo
, Pieter P.A.M. van Thiel
, Gerard J. Schoone
, Ymkje Stienstra
, Michèle van Vugt
, Jos H. Beijnen
, Peter J. de Vries

University of Amsterdam
Netherlands Cancer Institute
Royal Tropical Institute
University of Groningen

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ~1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.

Original language	English
Article number	e1436
Journal	PLoS Neglected Tropical Diseases
Volume	5
Issue number	12
DOIs	https://doi.org/10.1371/journal.pntd.0001436
Publication status	Published - 1 Dec 2011
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1371/journal.pntd.0001436Licence: CC BY

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AU - Stienstra, Ymkje

AU - van Vugt, Michèle

AU - Beijnen, Jos H.

AU - de Vries, Peter J.

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AB - Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ~1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.

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Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

Abstract

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