Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

Camila Alexandrina Figueiredo; Laura Cunha Rodrigues; Neuza Maria Alcantara-Neves; Philip Cooper; Leila Denise Amorim; Nivea Bispo Silva; Alvaro A Cruz; Mauricio Lima Barreto

doi:10.1186/1710-1492-8-18

Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

Camila Alexandrina Figueiredo
, Laura Cunha Rodrigues
, Neuza Maria Alcantara-Neves
, Philip Cooper
, Leila Denise Amorim
, Nivea Bispo Silva
, Alvaro A Cruz
, Mauricio Lima Barreto

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Letter › peer-review

12 Citations (Scopus)

Abstract

In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.

Original language	English
Article number	18
Pages (from-to)	e18
Journal	Allergy, Asthma and Clinical Immunology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1710-1492-8-18
Publication status	Published - 19 Dec 2012

Keywords

Atopic-asthma
Atopy
Cytokines
IFN-g
IgE
Monocytes
Non-atopic asthma

Access to Document

10.1186/1710-1492-8-18Licence: CC BY

Alle Asth Clin Imm 8 18Final published version, 502 KBLicence: CC BY

Cite this

@article{e2c7496a9fac42e29ca5e5b920e9a0c4,

title = "Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?",

abstract = "In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.",

keywords = "Atopic-asthma, Atopy, Cytokines, IFN-g, IgE, Monocytes, Non-atopic asthma",

author = "Figueiredo, \{Camila Alexandrina\} and Rodrigues, \{Laura Cunha\} and Alcantara-Neves, \{Neuza Maria\} and Philip Cooper and Amorim, \{Leila Denise\} and Silva, \{Nivea Bispo\} and Cruz, \{Alvaro A\} and Barreto, \{Mauricio Lima\}",

year = "2012",

month = dec,

day = "19",

doi = "10.1186/1710-1492-8-18",

language = "English",

volume = "8",

pages = "e18",

journal = "Allergy, Asthma and Clinical Immunology",

issn = "1710-1484",