Differentiating the pathologies of cerebral malaria by postmortem parasite counts

T. E. Taylor; W. J. J. Fu; R. A. Carr; R. O. Whitten; J. G. Mueller; N. G. Fosiko; S. Lewallen; N. G. Liomba; Malcolm E Molyneux

doi:10.1038/nm986

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

T. E. Taylor
, W. J. J. Fu
, R. A. Carr
, R. O. Whitten
, J. G. Mueller
, N. G. Fosiko
, S. Lewallen
, N. G. Liomba
, Malcolm E Molyneux

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

589 Citations (Scopus)

Abstract

To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

Original language	English
Pages (from-to)	143-145
Number of pages	3
Journal	Nature Medicine
Volume	10
Issue number	2
DOIs	https://doi.org/10.1038/nm986
Publication status	Published - 1 Feb 2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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abstract = "To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23\% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75\% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.",

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AU - Carr, R. A.

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AU - Mueller, J. G.

AU - Fosiko, N. G.

AU - Lewallen, S.

AU - Liomba, N. G.

AU - Molyneux, Malcolm E

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AB - To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

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Differentiating the pathologies of cerebral malaria by postmortem parasite counts

Abstract

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