Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda

Stephen Tukwasibwe; Levi Mugenyi; George W. Mbogo; Sheila Nankoberanyi; Catherine Maiteki-Sebuguzi; Moses L. Joloba; Samuel L. Nsobya; Sarah Staedke; Philip J. Rosenthal

doi:10.1093/infdis/jiu044

Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda

Stephen Tukwasibwe, Levi Mugenyi, George W. Mbogo, Sheila Nankoberanyi, Catherine Maiteki-Sebuguzi, Moses L. Joloba, Samuel L. Nsobya, Sarah Staedke, Philip J. Rosenthal

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children ( pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.

Original language	English
Pages (from-to)	154-157
Number of pages	4
Journal	Journal of Infectious Disease
Volume	210
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiu044
Publication status	Published - 1 Jul 2014
Externally published	Yes

Keywords

Fitness
Malaria
Plasmodium
Polymorphism
Virulence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiu044

Cite this

@article{71a1b2c678ea4fafa277d3210ae49b8c,

title = "Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda",

abstract = "We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children ( pfcrt K76T: odds ratio [OR] 4.41 [95\% confidence interval \{CI\}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95\% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95\% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.",

keywords = "Fitness, Malaria, Plasmodium, Polymorphism, Virulence",

author = "Stephen Tukwasibwe and Levi Mugenyi and Mbogo, \{George W.\} and Sheila Nankoberanyi and Catherine Maiteki-Sebuguzi and Joloba, \{Moses L.\} and Nsobya, \{Samuel L.\} and Sarah Staedke and Rosenthal, \{Philip J.\}",

year = "2014",

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day = "1",

doi = "10.1093/infdis/jiu044",

language = "English",

volume = "210",

pages = "154--157",

journal = "Journal of Infectious Disease",

number = "1",

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TY - JOUR

T1 - Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda

AU - Tukwasibwe, Stephen

AU - Mugenyi, Levi

AU - Mbogo, George W.

AU - Nankoberanyi, Sheila

AU - Maiteki-Sebuguzi, Catherine

AU - Joloba, Moses L.

AU - Nsobya, Samuel L.

AU - Staedke, Sarah

AU - Rosenthal, Philip J.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children ( pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.

AB - We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children ( pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.

KW - Fitness

KW - Malaria

KW - Plasmodium

KW - Polymorphism

KW - Virulence

U2 - 10.1093/infdis/jiu044

DO - 10.1093/infdis/jiu044

M3 - Article

VL - 210

SP - 154

EP - 157

JO - Journal of Infectious Disease

JF - Journal of Infectious Disease

IS - 1

ER -

Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda

Abstract

Keywords

UN SDGs

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