Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

Jamie Royle; Claire L. Donald; Andres Merits; Alain Kohl; Margus Varjak

doi:10.1016/j.tvjl.2017.10.009

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

Jamie Royle, Claire L. Donald, Andres Merits, Alain Kohl, Margus Varjak

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).

Original language	English
Pages (from-to)	62-64
Number of pages	3
Journal	Veterinary Journal
Volume	230
DOIs	https://doi.org/10.1016/j.tvjl.2017.10.009
Publication status	Published - 1 Dec 2017
Externally published	Yes

Keywords

Antiviral agent
Lipid biosynthesis
Semliki Forest virus
Zika virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tvjl.2017.10.009Licence: CC BY

Cite this

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title = "Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses",

abstract = "The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).",

keywords = "Antiviral agent, Lipid biosynthesis, Semliki Forest virus, Zika virus",

author = "Jamie Royle and Donald, \{Claire L.\} and Andres Merits and Alain Kohl and Margus Varjak",

year = "2017",

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doi = "10.1016/j.tvjl.2017.10.009",

language = "English",

volume = "230",

pages = "62--64",

journal = "Veterinary Journal",

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T1 - Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

AU - Royle, Jamie

AU - Donald, Claire L.

AU - Merits, Andres

AU - Kohl, Alain

AU - Varjak, Margus

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).

AB - The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).

KW - Antiviral agent

KW - Lipid biosynthesis

KW - Semliki Forest virus

KW - Zika virus

U2 - 10.1016/j.tvjl.2017.10.009

DO - 10.1016/j.tvjl.2017.10.009

M3 - Article

SN - 1090-0233

VL - 230

SP - 62

EP - 64

JO - Veterinary Journal

JF - Veterinary Journal

ER -

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

Abstract

Keywords

UN SDGs

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