Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8

G. M. Cull; J. M. Timms; A. P. Haynes; N. H. Russell; W. L. Irving; Jonathan Ball; B. J. Thomson

doi:10.1046/j.1365-2141.1998.00671.x

Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8

G. M. Cull, J. M. Timms, A. P. Haynes, N. H. Russell, W. L. Irving, Jonathan Ball, B. J. Thomson

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reported. This finding is of great potential importance regarding oncogenesis in myeloma in addition to having significant implications for the use of DC in the immunotherapy of this disease. Therefore DC generated from mobilized blood mononuclear cells (MO-DC) and purified CD34+ cells (CD34-DC) of myeloma patients were examined for the presence of HHV-8 using a sensitive PCR technique. HHV-8 was not demonstrated in MO-DC or CD34-DC and we conclude that these cells remain a suitable vehicle for investigation in the immunotherapy of myeloma.

Original language	English
Pages (from-to)	793-796
Number of pages	4
Journal	British Journal of Haematology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.1998.00671.x
Publication status	Published - 1 Jan 1998
Externally published	Yes

Keywords

Dendritic cells
Human herpesvirus 8
Immunotherapy
Myeloma

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.1998.00671.x

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title = "Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8",

abstract = "Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reported. This finding is of great potential importance regarding oncogenesis in myeloma in addition to having significant implications for the use of DC in the immunotherapy of this disease. Therefore DC generated from mobilized blood mononuclear cells (MO-DC) and purified CD34+ cells (CD34-DC) of myeloma patients were examined for the presence of HHV-8 using a sensitive PCR technique. HHV-8 was not demonstrated in MO-DC or CD34-DC and we conclude that these cells remain a suitable vehicle for investigation in the immunotherapy of myeloma.",

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year = "1998",

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doi = "10.1046/j.1365-2141.1998.00671.x",

language = "English",

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T1 - Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8

AU - Cull, G. M.

AU - Timms, J. M.

AU - Haynes, A. P.

AU - Russell, N. H.

AU - Irving, W. L.

AU - Ball, Jonathan

AU - Thomson, B. J.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reported. This finding is of great potential importance regarding oncogenesis in myeloma in addition to having significant implications for the use of DC in the immunotherapy of this disease. Therefore DC generated from mobilized blood mononuclear cells (MO-DC) and purified CD34+ cells (CD34-DC) of myeloma patients were examined for the presence of HHV-8 using a sensitive PCR technique. HHV-8 was not demonstrated in MO-DC or CD34-DC and we conclude that these cells remain a suitable vehicle for investigation in the immunotherapy of myeloma.

AB - Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reported. This finding is of great potential importance regarding oncogenesis in myeloma in addition to having significant implications for the use of DC in the immunotherapy of this disease. Therefore DC generated from mobilized blood mononuclear cells (MO-DC) and purified CD34+ cells (CD34-DC) of myeloma patients were examined for the presence of HHV-8 using a sensitive PCR technique. HHV-8 was not demonstrated in MO-DC or CD34-DC and we conclude that these cells remain a suitable vehicle for investigation in the immunotherapy of myeloma.

KW - Dendritic cells

KW - Human herpesvirus 8

KW - Immunotherapy

KW - Myeloma

U2 - 10.1046/j.1365-2141.1998.00671.x

DO - 10.1046/j.1365-2141.1998.00671.x

M3 - Article

SN - 0007-1048

VL - 100

SP - 793

EP - 796

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8

Abstract

Keywords

UN SDGs

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