Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance

Anthony M. Ndifor; Steve Ward; Robert E. Howells

doi:10.1016/0166-6851(90)90188-r

Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance

Anthony M. Ndifor, Steve Ward, Robert E. Howells

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Cytochrome P-450-dependent enzyme activities have been determined in malarial parasites. Both Plasmodium berghei and Plasmodium falciparum parasites exhibited activity and these activities were greater in chloroquine resistant parasites than in sensitive strains. This enzyme activity could be induced by phenobarbitone and inhibited by specific inhibitors of the cytochrome P-450 family of enzymes. The significance of these observations in parasite drug resistance is discussed.

Original language	English
Pages (from-to)	251-257
Number of pages	7
Journal	Molecular and Biochemical Parasitology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0166-6851(90)90188-r
Publication status	Published - 1 Jul 1990

Keywords

Cytochrome P-450
Malaria
Resistance

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10.1016/0166-6851(90)90188-r

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title = "Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance",

abstract = "Cytochrome P-450-dependent enzyme activities have been determined in malarial parasites. Both Plasmodium berghei and Plasmodium falciparum parasites exhibited activity and these activities were greater in chloroquine resistant parasites than in sensitive strains. This enzyme activity could be induced by phenobarbitone and inhibited by specific inhibitors of the cytochrome P-450 family of enzymes. The significance of these observations in parasite drug resistance is discussed.",

keywords = "Cytochrome P-450, Malaria, Resistance",

author = "Ndifor, \{Anthony M.\} and Steve Ward and Howells, \{Robert E.\}",

year = "1990",

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doi = "10.1016/0166-6851(90)90188-r",

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T1 - Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance

AU - Ndifor, Anthony M.

AU - Ward, Steve

AU - Howells, Robert E.

PY - 1990/7/1

Y1 - 1990/7/1

N2 - Cytochrome P-450-dependent enzyme activities have been determined in malarial parasites. Both Plasmodium berghei and Plasmodium falciparum parasites exhibited activity and these activities were greater in chloroquine resistant parasites than in sensitive strains. This enzyme activity could be induced by phenobarbitone and inhibited by specific inhibitors of the cytochrome P-450 family of enzymes. The significance of these observations in parasite drug resistance is discussed.

AB - Cytochrome P-450-dependent enzyme activities have been determined in malarial parasites. Both Plasmodium berghei and Plasmodium falciparum parasites exhibited activity and these activities were greater in chloroquine resistant parasites than in sensitive strains. This enzyme activity could be induced by phenobarbitone and inhibited by specific inhibitors of the cytochrome P-450 family of enzymes. The significance of these observations in parasite drug resistance is discussed.

KW - Cytochrome P-450

KW - Malaria

KW - Resistance

U2 - 10.1016/0166-6851(90)90188-r

DO - 10.1016/0166-6851(90)90188-r

M3 - Article

SN - 0166-6851

VL - 41

SP - 251

EP - 257

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 2

ER -

Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance

Abstract

Keywords

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