Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.

Natalia Yurievna Pshenichnaya; Hakan Leblebicioglu; Ilkay Bozkurt; Irina Viktorovna Sannikova; Gulzhan Narkenovna Abuova; Andrey Sergeevich Zhuravlev; Sener Barut; Mutabar Bekovna Shermetova; Tom Fletcher

doi:10.1016/j.ijid.2017.02.019

Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.

Natalia Yurievna Pshenichnaya
, Hakan Leblebicioglu
, Ilkay Bozkurt
, Irina Viktorovna Sannikova
, Gulzhan Narkenovna Abuova
, Andrey Sergeevich Zhuravlev
, Sener Barut
, Mutabar Bekovna Shermetova
, Tom Fletcher

Rostov State Medical University
Ondokuz Mayis University
Stavropol State Medical University
South Kazakhstan Medical Academy
Sechenov First Moscow State Medical University
Gaziosmanpasa University
Turkestan Central City Hospital

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Background

Crimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood.

Objectives

To systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey.

Methods

A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, SCOPUS, Science Citation Index (SCI) were searched for reports published between January 1960 and June 2016. Two independent reviewers selected and reviewed studies and extracted data.

Results

Thirty-four cases of CCHF in pregnancy were identified, and combined with the case series data, 42 cases were analyzed. The majority of cases originated in Turkey (14), Iran (10) and Russia (6). There was a maternal mortality of 14/41(34%) and fetal/neonatal mortality of in 24/41 cases (58.5%). Hemorrhage was associated with maternal (p = 0.009) and fetal/neonatal death (p < 0.0001). There was nosocomial transmission to 38 cases from 6/37 index pregnant cases.

Conclusion

Cases of CCHF in pregnancy are rare, but associated with high rates of maternal and fetal mortality, and nosocomial transmission.

Original language	English
Pages (from-to)	58-64
Number of pages	7
Journal	International Journal of Infectious Diseases
Volume	58
Early online date	27 Feb 2017
DOIs	https://doi.org/10.1016/j.ijid.2017.02.019
Publication status	Published - 1 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Crimean-Congo hemorrhagic fever
healthcare associated infection
pregnancy
viral hemorrhagic fever

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10.1016/j.ijid.2017.02.019Licence: CC BY

Int J Inf Dis 58 58-64 2017Final published version, 380 KBLicence: CC BY

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Pshenichnaya, N. Y., Leblebicioglu, H., Bozkurt, I., Sannikova, I. V., Abuova, G. N., Zhuravlev, A. S., Barut, S., Shermetova, M. B., & Fletcher, T. (2017). Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey. International Journal of Infectious Diseases, 58, 58-64. https://doi.org/10.1016/j.ijid.2017.02.019

@article{f43550aa0c884219aec2434f53972e66,

title = "Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.",

abstract = "BackgroundCrimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30\%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood.ObjectivesTo systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey.MethodsA systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, SCOPUS, Science Citation Index (SCI) were searched for reports published between January 1960 and June 2016. Two independent reviewers selected and reviewed studies and extracted data.ResultsThirty-four cases of CCHF in pregnancy were identified, and combined with the case series data, 42 cases were analyzed. The majority of cases originated in Turkey (14), Iran (10) and Russia (6). There was a maternal mortality of 14/41(34\%) and fetal/neonatal mortality of in 24/41 cases (58.5\%). Hemorrhage was associated with maternal (p = 0.009) and fetal/neonatal death (p < 0.0001). There was nosocomial transmission to 38 cases from 6/37 index pregnant cases.ConclusionCases of CCHF in pregnancy are rare, but associated with high rates of maternal and fetal mortality, and nosocomial transmission.",

keywords = "Crimean-Congo hemorrhagic fever, healthcare associated infection, pregnancy, viral hemorrhagic fever",

author = "Pshenichnaya, \{Natalia Yurievna\} and Hakan Leblebicioglu and Ilkay Bozkurt and Sannikova, \{Irina Viktorovna\} and Abuova, \{Gulzhan Narkenovna\} and Zhuravlev, \{Andrey Sergeevich\} and Sener Barut and Shermetova, \{Mutabar Bekovna\} and Tom Fletcher",

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T1 - Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.

AU - Pshenichnaya, Natalia Yurievna

AU - Leblebicioglu, Hakan

AU - Bozkurt, Ilkay

AU - Sannikova, Irina Viktorovna

AU - Abuova, Gulzhan Narkenovna

AU - Zhuravlev, Andrey Sergeevich

AU - Barut, Sener

AU - Shermetova, Mutabar Bekovna

AU - Fletcher, Tom

PY - 2017/5/1

Y1 - 2017/5/1

N2 - BackgroundCrimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood.ObjectivesTo systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey.MethodsA systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, SCOPUS, Science Citation Index (SCI) were searched for reports published between January 1960 and June 2016. Two independent reviewers selected and reviewed studies and extracted data.ResultsThirty-four cases of CCHF in pregnancy were identified, and combined with the case series data, 42 cases were analyzed. The majority of cases originated in Turkey (14), Iran (10) and Russia (6). There was a maternal mortality of 14/41(34%) and fetal/neonatal mortality of in 24/41 cases (58.5%). Hemorrhage was associated with maternal (p = 0.009) and fetal/neonatal death (p < 0.0001). There was nosocomial transmission to 38 cases from 6/37 index pregnant cases.ConclusionCases of CCHF in pregnancy are rare, but associated with high rates of maternal and fetal mortality, and nosocomial transmission.

AB - BackgroundCrimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood.ObjectivesTo systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey.MethodsA systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, SCOPUS, Science Citation Index (SCI) were searched for reports published between January 1960 and June 2016. Two independent reviewers selected and reviewed studies and extracted data.ResultsThirty-four cases of CCHF in pregnancy were identified, and combined with the case series data, 42 cases were analyzed. The majority of cases originated in Turkey (14), Iran (10) and Russia (6). There was a maternal mortality of 14/41(34%) and fetal/neonatal mortality of in 24/41 cases (58.5%). Hemorrhage was associated with maternal (p = 0.009) and fetal/neonatal death (p < 0.0001). There was nosocomial transmission to 38 cases from 6/37 index pregnant cases.ConclusionCases of CCHF in pregnancy are rare, but associated with high rates of maternal and fetal mortality, and nosocomial transmission.

KW - Crimean-Congo hemorrhagic fever

KW - healthcare associated infection

KW - pregnancy

KW - viral hemorrhagic fever

U2 - 10.1016/j.ijid.2017.02.019

DO - 10.1016/j.ijid.2017.02.019

M3 - Article

SN - 1201-9712

VL - 58

SP - 58

EP - 64

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.

Abstract

UN SDGs

Keywords

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