Control of malaria-transmitting mosquitoes using gene drives

Tony Nolan

doi:10.1098/rstb.2019.0803

Control of malaria-transmitting mosquitoes using gene drives

Tony Nolan

Vector Biology

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

Gene drives are selfish genetic elements that can be re-designed to invade a population and they hold tremendous potential for the control of mosquitoes that transmit disease. Much progress has been made recently in demonstrating proof of principle for gene drives able to suppress populations of malarial mosquitoes, or to make them refractory to the Plasmodium parasites they transmit. This has been achieved using CRISPR-based gene drives. In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control.

Original language	English
Article number	20190803
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	376
Issue number	1818
Early online date	28 Dec 2020
DOIs	https://doi.org/10.1098/rstb.2019.0803
Publication status	Published - 15 Feb 2021

Keywords

anopheles
CRISPR
gene drive
mosquito
transgenic
vector control

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1098/rstb.2019.0803

Cite this

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AB - Gene drives are selfish genetic elements that can be re-designed to invade a population and they hold tremendous potential for the control of mosquitoes that transmit disease. Much progress has been made recently in demonstrating proof of principle for gene drives able to suppress populations of malarial mosquitoes, or to make them refractory to the Plasmodium parasites they transmit. This has been achieved using CRISPR-based gene drives. In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control.

KW - anopheles

KW - CRISPR

KW - gene drive

KW - mosquito

KW - transgenic

KW - vector control

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DO - 10.1098/rstb.2019.0803

M3 - Review article

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VL - 376

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

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ER -

Control of malaria-transmitting mosquitoes using gene drives

Abstract

Keywords

UN SDGs

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