Control lymphocyte subsets: Can one country's values serve for another's?

Wilson L. Mandala; Jintanat Ananworanich; Tanakorn Apornpong; Stephen J. Kerr; Jenny M. MacLennan; Celine Hanson; Tanyathip Jaimulwong; Esther Gondwe; Howard M. Rosenblatt; Torsak Bunupuradah; Malcolm E Molyneux; Stephen A. Spector; Chitsanu Pancharoen; Rebecca S. Gelman; Calman A. MacLennan; William T. Shearer

doi:10.1016/j.jaci.2014.06.030

Control lymphocyte subsets: Can one country's values serve for another's?

Wilson L. Mandala, Jintanat Ananworanich, Tanakorn Apornpong, Stephen J. Kerr, Jenny M. MacLennan, Celine Hanson, Tanyathip Jaimulwong, Esther Gondwe, Howard M. Rosenblatt, Torsak Bunupuradah, Malcolm E Molyneux, Stephen A. Spector, Chitsanu Pancharoen, Rebecca S. Gelman, Calman A. MacLennan, William T. Shearer

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Reliable interpretation of abnormal immunity depends on an understanding of what constitutes “normal.” We and others have reported that lymphocyte patterns are affected by ethnicity, sex, and environmental factors.1-3 Differing exposure to infectious agents, such as malaria, tuberculosis, and cytomegalovirus, could underlie differences in lymphocyte subset patterns in contrasting settings.4-6 In this study we analyzed combined data from 3 studies of healthy children from Thailand,1 Malawi,2 and the United States 3 who had used similar standard flow cytometric methods and markers, thus allowing assessment of immune heterogeneity across settings with differences in ethnicity and infectious disease exposure.

Original language	English
Pages (from-to)	759-761.e8
Journal	Journal of Allergy and Clinical Immunology
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/j.jaci.2014.06.030
Publication status	Published - 1 Sept 2014

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10.1016/j.jaci.2014.06.030

Cite this

Mandala, W. L., Ananworanich, J., Apornpong, T., Kerr, S. J., MacLennan, J. M., Hanson, C., Jaimulwong, T., Gondwe, E., Rosenblatt, H. M., Bunupuradah, T., Molyneux, M. E., Spector, S. A., Pancharoen, C., Gelman, R. S., MacLennan, C. A., & Shearer, W. T. (2014). Control lymphocyte subsets: Can one country's values serve for another's? Journal of Allergy and Clinical Immunology, 134(3), 759-761.e8. https://doi.org/10.1016/j.jaci.2014.06.030

@article{20c8f064e3394ad382f06e4d6fd95dc1,

title = "Control lymphocyte subsets: Can one country's values serve for another's?",

abstract = "Reliable interpretation of abnormal immunity depends on an understanding of what constitutes “normal.” We and others have reported that lymphocyte patterns are affected by ethnicity, sex, and environmental factors.1-3 Differing exposure to infectious agents, such as malaria, tuberculosis, and cytomegalovirus, could underlie differences in lymphocyte subset patterns in contrasting settings.4-6 In this study we analyzed combined data from 3 studies of healthy children from Thailand,1 Malawi,2 and the United States 3 who had used similar standard flow cytometric methods and markers, thus allowing assessment of immune heterogeneity across settings with differences in ethnicity and infectious disease exposure.",

author = "Mandala, \{Wilson L.\} and Jintanat Ananworanich and Tanakorn Apornpong and Kerr, \{Stephen J.\} and MacLennan, \{Jenny M.\} and Celine Hanson and Tanyathip Jaimulwong and Esther Gondwe and Rosenblatt, \{Howard M.\} and Torsak Bunupuradah and Molyneux, \{Malcolm E\} and Spector, \{Stephen A.\} and Chitsanu Pancharoen and Gelman, \{Rebecca S.\} and MacLennan, \{Calman A.\} and Shearer, \{William T.\}",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.jaci.2014.06.030",

language = "English",

volume = "134",

pages = "759--761.e8",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",