Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study

Tom Wingfield; Peter MacPherson; P. Sodha; A. Tucker; J. Mithoo; Bertie Squire; P. Cleary

doi:10.5588/ijtld.18.0467

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study

Tom Wingfield, Peter MacPherson, P. Sodha, A. Tucker, J. Mithoo, Bertie Squire, P. Cleary

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

OBJECTIVE

To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.

DESIGN

This was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support).

RESULTS

A total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0-25).

CONCLUSIONS

The social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	23
Issue number	3
DOIs	https://doi.org/10.5588/ijtld.18.0467
Publication status	Published - 1 Mar 2019

Keywords

Contact screening
Enhanced case management
Public health
Social and clinical complexity
TB
TB control
TB prevention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study",

abstract = "OBJECTIVETo investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.DESIGNThis was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support).RESULTSA total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smear-positive vs. smear-negative, OR 5.3, 95\%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95\%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95\%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smear-positive vs. smear-negative, OR 5.3, 95\%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95\%CI 2.0-25).CONCLUSIONSThe social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.",

keywords = "Contact screening, Enhanced case management, Public health, Social and clinical complexity, TB, TB control, TB prevention",

author = "Tom Wingfield and Peter MacPherson and P. Sodha and A. Tucker and J. Mithoo and Bertie Squire and P. Cleary",

year = "2019",

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doi = "10.5588/ijtld.18.0467",

language = "English",

volume = "23",

pages = "337--343",

journal = "International Journal of Tuberculosis and Lung Disease",

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publisher = "International Union Against Tuberculosis and Lung Disease ",

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T1 - Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study

AU - Wingfield, Tom

AU - MacPherson, Peter

AU - Sodha, P.

AU - Tucker, A.

AU - Mithoo, J.

AU - Squire, Bertie

AU - Cleary, P.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - OBJECTIVETo investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.DESIGNThis was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support).RESULTSA total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0-25).CONCLUSIONSThe social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

AB - OBJECTIVETo investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.DESIGNThis was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support).RESULTSA total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0-25).CONCLUSIONSThe social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

KW - Contact screening

KW - Enhanced case management

KW - Public health

KW - Social and clinical complexity

KW - TB

KW - TB control

KW - TB prevention

U2 - 10.5588/ijtld.18.0467

DO - 10.5588/ijtld.18.0467

M3 - Article

SN - 1027-3719

VL - 23

SP - 337

EP - 343

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 3

ER -

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study

Abstract

Keywords

UN SDGs

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