Comparison and critical appraisal of dengue clinical guidelines and their use in Asia and Latin America

R. Santamaria, E. Martinez, S. Kratochwill, C. Soria, L.H. Tan, A. Nuñez, E. Dimaano, E. Villegas, H. Bendezú, Axel Kroeger, I. Castelobranco, J.B. Siqueira, T. Jaenisch, O. Horstick, L.C.S. Lum

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Summary The World Health Organization (WHO) dengue classification scheme for dengue

fever (DF) and dengue haemorrhagic fever (DHF)/dengue shock syndrome (DSS) has been

adopted as the standard for diagnosis, clinical management and reporting. In recent years,

difficulties in applying the WHO case classification have been reported in several countries.

A multicenter study was carried out in Asia and Latin America to analyze the variation and

utility of dengue clinical guidelines (DCGs) taking as reference the WHO/PAHO guidelines

(1994) and the WHO/SEARO guidelines (1998). A document analysis of 13 dengue guidelines

was followed by a questionnaire and Focus Group discussions (FGDs) with 858 health care

providers in seven countries. Differences in DCGs of the 13 countries were identified including the concept of warning signs, case classification, use of treatment algorithms and grading into

levels of severity. The questionnaires and FGDs revealed (1) inaccessibility of DCGs, (2) lack of

training, (3) insufficient number of staff to correctly apply the DCGs at the frontline and (4)

the unavailability of diagnostic tests. The differences of the DCGs and the inconsistency in their

application suggest a need to re-evaluate and standardise DCGs. This applies especially to case

classification and case management.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalInternational Health
Volume1
Issue number2
DOIs
Publication statusPublished - 1 Dec 2009
Externally publishedYes

Keywords

  • Case classification
  • Clinical guidelines
  • Dengue
  • Dengue fever
  • Dengue haemorrhagic fever
  • Disease management

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