Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study

Nicholaus P. Mnyambwa; Clara Lubinza; Esther Ngadaya; Mbazi Senkoro; Godfather Kimaro; Gibson B. Kagaruki; Stanley Binagi; Amani Malima; Paul Kazyoba; Ndekya Oriyo; Janneth M. Mghamba; Aman Fredrick; Kaushik Ramaiya; Alimuddin Zumla; Shabbar Jaffar; Sayoki G. Mfinanga

doi:10.1016/j.ijregi.2021.12.010

Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study

Nicholaus P. Mnyambwa, Clara Lubinza, Esther Ngadaya, Mbazi Senkoro, Godfather Kimaro, Gibson B. Kagaruki, Stanley Binagi, Amani Malima, Paul Kazyoba, Ndekya Oriyo, Janneth M. Mghamba, Aman Fredrick, Kaushik Ramaiya, Alimuddin Zumla, Shabbar Jaffar, Sayoki G. Mfinanga

International Public Health

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background

We performed a prospective cohort study of the clinical presentations and management outcomes of laboratory-confirmed COVID-19 patients in the early months of the pandemic at two hospitals in Dar es Salaam, Tanzania.

Methods

Between April 1 - May 31, 2020, laboratory-confirmed COVID-19 patients seen at two tertiary facilities were consecutively enrolled in the study and followed up for 21 days.

Results

We enrolled 121 COVID-19 patients; 112 (92.6%) were admitted while 9 (7.4%) were seen as outpatients. The median (IQR) age of patients was 41 (30-54) years; 72 (59.5%) were male. The medians (IQR) reported days from hospital admission to recovery and death was 10 (6-18) and 5.5 (3-9), respectively. Forty-four (36.4%) patients had at least one underlying condition. Of the 112 admissions, 17 (15.2%) went to ICU, of which 14 (82.3%) died. At the end of follow-up, 93(76.9%) recovered, and 18 (14.9%) died, 7 (5.8%) remained asymptomatic, and 1 (0.8%) was still ill. Overall, 46 (38.3%) patients had at least one underlying condition.

Conclusion

Three-quarters of all COVID-19 patients were aged less than 60 years, reflecting Africa's young population structure. High admission rates to ICU and death rates were observed.

Original language	English
Pages (from-to)	118-125
Number of pages	8
Journal	IJID Regions
Volume	2
Early online date	6 Jan 2022
DOIs	https://doi.org/10.1016/j.ijregi.2021.12.010
Publication status	Published - 1 Mar 2022

Keywords

clinical outcome
COVID-19
SARS-Cov-2

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10.1016/j.ijregi.2021.12.010Licence: CC BY-NC-ND

Covid 19 revised 29 08 2021 for CID(1)Accepted author manuscript, 251 KBLicence: CC BY-NC-ND

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Mnyambwa, N. P., Lubinza, C., Ngadaya, E., Senkoro, M., Kimaro, G., Kagaruki, G. B., Binagi, S., Malima, A., Kazyoba, P., Oriyo, N., Mghamba, J. M., Fredrick, A., Ramaiya, K., Zumla, A., Jaffar, S., & Mfinanga, S. G. (2022). Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study. IJID Regions, 2, 118-125. https://doi.org/10.1016/j.ijregi.2021.12.010

@article{63a587fd71984a3abd55dae9f493a00b,

title = "Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study",

abstract = "BackgroundWe performed a prospective cohort study of the clinical presentations and management outcomes of laboratory-confirmed COVID-19 patients in the early months of the pandemic at two hospitals in Dar es Salaam, Tanzania.MethodsBetween April 1 - May 31, 2020, laboratory-confirmed COVID-19 patients seen at two tertiary facilities were consecutively enrolled in the study and followed up for 21 days.ResultsWe enrolled 121 COVID-19 patients; 112 (92.6\%) were admitted while 9 (7.4\%) were seen as outpatients. The median (IQR) age of patients was 41 (30-54) years; 72 (59.5\%) were male. The medians (IQR) reported days from hospital admission to recovery and death was 10 (6-18) and 5.5 (3-9), respectively. Forty-four (36.4\%) patients had at least one underlying condition. Of the 112 admissions, 17 (15.2\%) went to ICU, of which 14 (82.3\%) died. At the end of follow-up, 93(76.9\%) recovered, and 18 (14.9\%) died, 7 (5.8\%) remained asymptomatic, and 1 (0.8\%) was still ill. Overall, 46 (38.3\%) patients had at least one underlying condition.ConclusionThree-quarters of all COVID-19 patients were aged less than 60 years, reflecting Africa's young population structure. High admission rates to ICU and death rates were observed.",

keywords = "clinical outcome, COVID-19, SARS-Cov-2",

author = "Mnyambwa, \{Nicholaus P.\} and Clara Lubinza and Esther Ngadaya and Mbazi Senkoro and Godfather Kimaro and Kagaruki, \{Gibson B.\} and Stanley Binagi and Amani Malima and Paul Kazyoba and Ndekya Oriyo and Mghamba, \{Janneth M.\} and Aman Fredrick and Kaushik Ramaiya and Alimuddin Zumla and Shabbar Jaffar and Mfinanga, \{Sayoki G.\}",

year = "2022",

month = mar,

day = "1",

doi = "10.1016/j.ijregi.2021.12.010",

language = "English",

volume = "2",

pages = "118--125",

journal = "IJID Regions",

issn = "2772-7076",

publisher = "Elsevier Ltd",

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Mnyambwa, NP, Lubinza, C, Ngadaya, E, Senkoro, M, Kimaro, G, Kagaruki, GB, Binagi, S, Malima, A, Kazyoba, P, Oriyo, N, Mghamba, JM, Fredrick, A, Ramaiya, K, Zumla, A, Jaffar, S & Mfinanga, SG 2022, 'Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study', IJID Regions, vol. 2, pp. 118-125. https://doi.org/10.1016/j.ijregi.2021.12.010

TY - JOUR

T1 - Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study

AU - Mnyambwa, Nicholaus P.

AU - Lubinza, Clara

AU - Ngadaya, Esther

AU - Senkoro, Mbazi

AU - Kimaro, Godfather

AU - Kagaruki, Gibson B.

AU - Binagi, Stanley

AU - Malima, Amani

AU - Kazyoba, Paul

AU - Oriyo, Ndekya

AU - Mghamba, Janneth M.

AU - Fredrick, Aman

AU - Ramaiya, Kaushik

AU - Zumla, Alimuddin

AU - Jaffar, Shabbar

AU - Mfinanga, Sayoki G.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - BackgroundWe performed a prospective cohort study of the clinical presentations and management outcomes of laboratory-confirmed COVID-19 patients in the early months of the pandemic at two hospitals in Dar es Salaam, Tanzania.MethodsBetween April 1 - May 31, 2020, laboratory-confirmed COVID-19 patients seen at two tertiary facilities were consecutively enrolled in the study and followed up for 21 days.ResultsWe enrolled 121 COVID-19 patients; 112 (92.6%) were admitted while 9 (7.4%) were seen as outpatients. The median (IQR) age of patients was 41 (30-54) years; 72 (59.5%) were male. The medians (IQR) reported days from hospital admission to recovery and death was 10 (6-18) and 5.5 (3-9), respectively. Forty-four (36.4%) patients had at least one underlying condition. Of the 112 admissions, 17 (15.2%) went to ICU, of which 14 (82.3%) died. At the end of follow-up, 93(76.9%) recovered, and 18 (14.9%) died, 7 (5.8%) remained asymptomatic, and 1 (0.8%) was still ill. Overall, 46 (38.3%) patients had at least one underlying condition.ConclusionThree-quarters of all COVID-19 patients were aged less than 60 years, reflecting Africa's young population structure. High admission rates to ICU and death rates were observed.

AB - BackgroundWe performed a prospective cohort study of the clinical presentations and management outcomes of laboratory-confirmed COVID-19 patients in the early months of the pandemic at two hospitals in Dar es Salaam, Tanzania.MethodsBetween April 1 - May 31, 2020, laboratory-confirmed COVID-19 patients seen at two tertiary facilities were consecutively enrolled in the study and followed up for 21 days.ResultsWe enrolled 121 COVID-19 patients; 112 (92.6%) were admitted while 9 (7.4%) were seen as outpatients. The median (IQR) age of patients was 41 (30-54) years; 72 (59.5%) were male. The medians (IQR) reported days from hospital admission to recovery and death was 10 (6-18) and 5.5 (3-9), respectively. Forty-four (36.4%) patients had at least one underlying condition. Of the 112 admissions, 17 (15.2%) went to ICU, of which 14 (82.3%) died. At the end of follow-up, 93(76.9%) recovered, and 18 (14.9%) died, 7 (5.8%) remained asymptomatic, and 1 (0.8%) was still ill. Overall, 46 (38.3%) patients had at least one underlying condition.ConclusionThree-quarters of all COVID-19 patients were aged less than 60 years, reflecting Africa's young population structure. High admission rates to ICU and death rates were observed.

KW - clinical outcome

KW - COVID-19

KW - SARS-Cov-2

U2 - 10.1016/j.ijregi.2021.12.010

DO - 10.1016/j.ijregi.2021.12.010

M3 - Article

SN - 2772-7076

VL - 2

SP - 118

EP - 125

JO - IJID Regions

JF - IJID Regions

ER -

Clinical characteristics and outcomes of confirmed COVID-19 patients in the early months of the pandemic in Tanzania: A multicentre cohort study

Abstract

Keywords

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