Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe

Dominik Stelzle; Annette Abraham; Miriam Kaminski; Veronika Schmidt; Robert De Meijere; Javier A. Bustos; Hector Hugo Garcia; Priyadarshi Soumyaranjan Sahu; Branko Bobić; Carmen Cretu; Peter Chiodini; Veronique Dermauw; Brecht Devleesschauwer; Pierre Dorny; Ana Fonseca; Sarah Gabriël; Maria Ángeles Gómez Morales; Minerva Laranjo-González; Achim Hoerauf; Ewan Hunter; Ronan Jambou; Maja Jurhar-Pavlova; Ingrid Reiter-Owona; Smaragda Sotiraki; Chiara Trevisan; Manuela Vilhena; Naomi Walker; Lorenzo Zammarchi; Andrea Sylvia Winkler

doi:10.1093/jtm/taac102

Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe

Dominik Stelzle
, Annette Abraham
, Miriam Kaminski
, Veronika Schmidt
, Robert De Meijere
, Javier A. Bustos
, Hector Hugo Garcia
, Priyadarshi Soumyaranjan Sahu
, Branko Bobić
, Carmen Cretu
, Peter Chiodini
, Veronique Dermauw
, Brecht Devleesschauwer
, Pierre Dorny
, Ana Fonseca
, Sarah Gabriël
, Maria Ángeles Gómez Morales
, Minerva Laranjo-González
, Achim Hoerauf
, Ewan Hunter

Ronan Jambou, Maja Jurhar-Pavlova, Ingrid Reiter-Owona, Smaragda Sotiraki, Chiara Trevisan, Manuela Vilhena, Naomi Walker, Lorenzo Zammarchi, Andrea Sylvia Winkler

Clinical Sciences

Technical University of Munich
University of Oslo
Charité – Universitätsmedizin Berlin
Instituto Nacional de Ciencias Neurológicas
Medical University of the Americas
University of Belgrade
Carol Davila University of Medicine and Pharmacy
Hospital for Tropical Diseases
London School of Hygiene and Tropical Medicine
Institute of Tropical Medicine Antwerp
Ghent University
NOVA University Lisbon
Istituto Superiore di Sanita
Campus UAB
University of Bonn
Partner Site Bonn-Cologne
Newcastle upon Tyne Hospitals NHS Foundation Trust
Institut Pasteur Paris
SS Cyril and Methodius University in Skopje
Veterinary Research Institute
University of Évora
University of Florence

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Objectives

Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of the tapeworm Taenia solium. NCC mainly occurs in Africa, Latin America and South-East Asia and can cause a variety of clinical signs/symptoms. Although it is a rare disease in Europe, it should nonetheless be considered as a differential diagnosis. The aim of this study was to describe clinical characteristics and management of patients with NCC diagnosed and treated in Europe.

Methods

We conducted a systematic search of published and unpublished data on patients diagnosed with NCC in Europe (2000–2019) and extracted demographic, clinical and radiological information on each case, if available.

Results

Out of 293 identified NCC cases, 59% of patients presented initially with epileptic seizures (21% focal onset); 52% presented with headache and 54% had other neurological signs/symptoms. The majority of patients had a travel or migration history (76%), mostly from/to Latin America (38%), Africa (32%) or Asia (30%). Treatment varied largely depending on cyst location and number. The outcome was favorable in 90% of the cases.

Conclusions

Management of NCC in Europe varied considerably but often had a good outcome. Travel and migration to and from areas endemic for T. solium will likely result in continued low prevalence of NCC in Europe. Therefore, training and guidance of clinicians is recommended for optimal patient management.

Original language	English
Article number	taac102
Pages (from-to)	etaac102
Journal	Journal of Travel Medicine
Volume	30
Issue number	1
Early online date	12 Oct 2022
DOIs	https://doi.org/10.1093/jtm/taac102
Publication status	Published - 12 Oct 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clinical epidemiology
Europe
Global Health
NCC management
neglected tropical diseases
Neurocysticercosis
One Health
Taenia solium

Access to Document

10.1093/jtm/taac102

NCC JTM 22August2022 publication[37]Accepted author manuscript, 632 KB

Cite this

Stelzle, D., Abraham, A., Kaminski, M., Schmidt, V., De Meijere, R., Bustos, J. A., Garcia, H. H., Sahu, P. S., Bobić, B., Cretu, C., Chiodini, P., Dermauw, V., Devleesschauwer, B., Dorny, P., Fonseca, A., Gabriël, S., Morales, M. Á. G., Laranjo-González, M., Hoerauf, A., ... Winkler, A. S. (2022). Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe. Journal of Travel Medicine, 30(1), etaac102. Article taac102. https://doi.org/10.1093/jtm/taac102

@article{f45b267536c048ad889a8b344806d6ad,

title = "Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe",

abstract = "Objectives Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of the tapeworm Taenia solium. NCC mainly occurs in Africa, Latin America and South-East Asia and can cause a variety of clinical signs/symptoms. Although it is a rare disease in Europe, it should nonetheless be considered as a differential diagnosis. The aim of this study was to describe clinical characteristics and management of patients with NCC diagnosed and treated in Europe. Methods We conducted a systematic search of published and unpublished data on patients diagnosed with NCC in Europe (2000–2019) and extracted demographic, clinical and radiological information on each case, if available. Results Out of 293 identified NCC cases, 59\% of patients presented initially with epileptic seizures (21\% focal onset); 52\% presented with headache and 54\% had other neurological signs/symptoms. The majority of patients had a travel or migration history (76\%), mostly from/to Latin America (38\%), Africa (32\%) or Asia (30\%). Treatment varied largely depending on cyst location and number. The outcome was favorable in 90\% of the cases. Conclusions Management of NCC in Europe varied considerably but often had a good outcome. Travel and migration to and from areas endemic for T. solium will likely result in continued low prevalence of NCC in Europe. Therefore, training and guidance of clinicians is recommended for optimal patient management.",

keywords = "Clinical epidemiology, Europe, Global Health, NCC management, neglected tropical diseases, Neurocysticercosis, One Health, Taenia solium",

author = "Dominik Stelzle and Annette Abraham and Miriam Kaminski and Veronika Schmidt and \{De Meijere\}, Robert and Bustos, \{Javier A.\} and Garcia, \{Hector Hugo\} and Sahu, \{Priyadarshi Soumyaranjan\} and Branko Bobi{\'c} and Carmen Cretu and Peter Chiodini and Veronique Dermauw and Brecht Devleesschauwer and Pierre Dorny and Ana Fonseca and Sarah Gabri{\"e}l and Morales, \{Maria {\'A}ngeles G{\'o}mez\} and Minerva Laranjo-Gonz{\'a}lez and Achim Hoerauf and Ewan Hunter and Ronan Jambou and Maja Jurhar-Pavlova and Ingrid Reiter-Owona and Smaragda Sotiraki and Chiara Trevisan and Manuela Vilhena and Naomi Walker and Lorenzo Zammarchi and Winkler, \{Andrea Sylvia\}",

year = "2022",

month = oct,

day = "12",

doi = "10.1093/jtm/taac102",

language = "English",

volume = "30",

pages = "etaac102",

journal = "Journal of Travel Medicine",

issn = "1195-1982",

publisher = "Oxford University Press",

number = "1",

}

Stelzle, D, Abraham, A, Kaminski, M, Schmidt, V, De Meijere, R, Bustos, JA, Garcia, HH, Sahu, PS, Bobić, B, Cretu, C, Chiodini, P, Dermauw, V, Devleesschauwer, B, Dorny, P, Fonseca, A, Gabriël, S, Morales, MÁG, Laranjo-González, M, Hoerauf, A, Hunter, E, Jambou, R, Jurhar-Pavlova, M, Reiter-Owona, I, Sotiraki, S, Trevisan, C, Vilhena, M, Walker, N, Zammarchi, L & Winkler, AS 2022, 'Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe', Journal of Travel Medicine, vol. 30, no. 1, taac102, pp. etaac102. https://doi.org/10.1093/jtm/taac102

TY - JOUR

T1 - Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe

AU - Stelzle, Dominik

AU - Abraham, Annette

AU - Kaminski, Miriam

AU - Schmidt, Veronika

AU - De Meijere, Robert

AU - Bustos, Javier A.

AU - Garcia, Hector Hugo

AU - Sahu, Priyadarshi Soumyaranjan

AU - Bobić, Branko

AU - Cretu, Carmen

AU - Chiodini, Peter

AU - Dermauw, Veronique

AU - Devleesschauwer, Brecht

AU - Dorny, Pierre

AU - Fonseca, Ana

AU - Gabriël, Sarah

AU - Morales, Maria Ángeles Gómez

AU - Laranjo-González, Minerva

AU - Hoerauf, Achim

AU - Hunter, Ewan

AU - Jambou, Ronan

AU - Jurhar-Pavlova, Maja

AU - Reiter-Owona, Ingrid

AU - Sotiraki, Smaragda

AU - Trevisan, Chiara

AU - Vilhena, Manuela

AU - Walker, Naomi

AU - Zammarchi, Lorenzo

AU - Winkler, Andrea Sylvia

PY - 2022/10/12

Y1 - 2022/10/12

N2 - Objectives Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of the tapeworm Taenia solium. NCC mainly occurs in Africa, Latin America and South-East Asia and can cause a variety of clinical signs/symptoms. Although it is a rare disease in Europe, it should nonetheless be considered as a differential diagnosis. The aim of this study was to describe clinical characteristics and management of patients with NCC diagnosed and treated in Europe. Methods We conducted a systematic search of published and unpublished data on patients diagnosed with NCC in Europe (2000–2019) and extracted demographic, clinical and radiological information on each case, if available. Results Out of 293 identified NCC cases, 59% of patients presented initially with epileptic seizures (21% focal onset); 52% presented with headache and 54% had other neurological signs/symptoms. The majority of patients had a travel or migration history (76%), mostly from/to Latin America (38%), Africa (32%) or Asia (30%). Treatment varied largely depending on cyst location and number. The outcome was favorable in 90% of the cases. Conclusions Management of NCC in Europe varied considerably but often had a good outcome. Travel and migration to and from areas endemic for T. solium will likely result in continued low prevalence of NCC in Europe. Therefore, training and guidance of clinicians is recommended for optimal patient management.

AB - Objectives Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of the tapeworm Taenia solium. NCC mainly occurs in Africa, Latin America and South-East Asia and can cause a variety of clinical signs/symptoms. Although it is a rare disease in Europe, it should nonetheless be considered as a differential diagnosis. The aim of this study was to describe clinical characteristics and management of patients with NCC diagnosed and treated in Europe. Methods We conducted a systematic search of published and unpublished data on patients diagnosed with NCC in Europe (2000–2019) and extracted demographic, clinical and radiological information on each case, if available. Results Out of 293 identified NCC cases, 59% of patients presented initially with epileptic seizures (21% focal onset); 52% presented with headache and 54% had other neurological signs/symptoms. The majority of patients had a travel or migration history (76%), mostly from/to Latin America (38%), Africa (32%) or Asia (30%). Treatment varied largely depending on cyst location and number. The outcome was favorable in 90% of the cases. Conclusions Management of NCC in Europe varied considerably but often had a good outcome. Travel and migration to and from areas endemic for T. solium will likely result in continued low prevalence of NCC in Europe. Therefore, training and guidance of clinicians is recommended for optimal patient management.

KW - Clinical epidemiology

KW - Europe

KW - Global Health

KW - NCC management

KW - neglected tropical diseases

KW - Neurocysticercosis

KW - One Health

KW - Taenia solium

U2 - 10.1093/jtm/taac102

DO - 10.1093/jtm/taac102

M3 - Review article

SN - 1195-1982

VL - 30

SP - etaac102

JO - Journal of Travel Medicine

JF - Journal of Travel Medicine

IS - 1

M1 - taac102

ER -

Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe

Abstract

UN SDGs

Keywords

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