Chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in Cameroon

Anthony M. Ndifor; Robert E. Howells; Steve Ward

doi:10.1016/0035-9203(92)90284-j

Chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in Cameroon

Anthony M. Ndifor
, Robert E. Howells
, Steve Ward

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Chloroquine-resistant Plasmodium falciparum has been reported in the Sahel and forest regions of Cameroon since 1985. In vivo response to chloroquine treatment (25 mg/kg) was assessed in 19 patients with malaria in the savanna North-West province. 58% of the cases showed RII resistance to chloroquine. RIII resistance was suspected in one patient. Only 35% of cases showed complete parasite clearance by day 5 of treatment. Chloroquine reduced parasite counts by at least 87% in all patients. Chloroquine resistance now seems to be well established and widespread in Cameroon. Its rapid spread and the prevalence of resistance suggest the existence of sustained drug pressure resulting in rapid selection of less sensitive strains. Unfortunately, similar pressure is also being exerted with quinine.

Original language	English
Pages (from-to)	229-230
Number of pages	2
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	86
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(92)90284-j
Publication status	Published - 1 Jun 1992

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title = "Chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in Cameroon",

abstract = "Chloroquine-resistant Plasmodium falciparum has been reported in the Sahel and forest regions of Cameroon since 1985. In vivo response to chloroquine treatment (25 mg/kg) was assessed in 19 patients with malaria in the savanna North-West province. 58\% of the cases showed RII resistance to chloroquine. RIII resistance was suspected in one patient. Only 35\% of cases showed complete parasite clearance by day 5 of treatment. Chloroquine reduced parasite counts by at least 87\% in all patients. Chloroquine resistance now seems to be well established and widespread in Cameroon. Its rapid spread and the prevalence of resistance suggest the existence of sustained drug pressure resulting in rapid selection of less sensitive strains. Unfortunately, similar pressure is also being exerted with quinine.",

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T1 - Chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in Cameroon

AU - Ndifor, Anthony M.

AU - Howells, Robert E.

AU - Ward, Steve

PY - 1992/6/1

Y1 - 1992/6/1

N2 - Chloroquine-resistant Plasmodium falciparum has been reported in the Sahel and forest regions of Cameroon since 1985. In vivo response to chloroquine treatment (25 mg/kg) was assessed in 19 patients with malaria in the savanna North-West province. 58% of the cases showed RII resistance to chloroquine. RIII resistance was suspected in one patient. Only 35% of cases showed complete parasite clearance by day 5 of treatment. Chloroquine reduced parasite counts by at least 87% in all patients. Chloroquine resistance now seems to be well established and widespread in Cameroon. Its rapid spread and the prevalence of resistance suggest the existence of sustained drug pressure resulting in rapid selection of less sensitive strains. Unfortunately, similar pressure is also being exerted with quinine.

AB - Chloroquine-resistant Plasmodium falciparum has been reported in the Sahel and forest regions of Cameroon since 1985. In vivo response to chloroquine treatment (25 mg/kg) was assessed in 19 patients with malaria in the savanna North-West province. 58% of the cases showed RII resistance to chloroquine. RIII resistance was suspected in one patient. Only 35% of cases showed complete parasite clearance by day 5 of treatment. Chloroquine reduced parasite counts by at least 87% in all patients. Chloroquine resistance now seems to be well established and widespread in Cameroon. Its rapid spread and the prevalence of resistance suggest the existence of sustained drug pressure resulting in rapid selection of less sensitive strains. Unfortunately, similar pressure is also being exerted with quinine.

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DO - 10.1016/0035-9203(92)90284-j

M3 - Article

SN - 0035-9203

VL - 86

SP - 229

EP - 230

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 3

ER -

Chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in Cameroon

Abstract

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