Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda

Patrick Tumwebaze; Stephen Tukwasibwe; Aimee Taylor; Melissa Conrad; Emmanuel Ruhamyankaka; Victor Asua; Andrew Walakira; Joaniter Nankabirwa; Adoke Yeka; Sarah Staedke; Bryan Greenhouse; Samuel L. Nsobya; Moses R. Kamya; Grant Dorsey; Philip J. Rosenthal

doi:10.1093/infdis/jiw614

Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda

Patrick Tumwebaze
, Stephen Tukwasibwe
, Aimee Taylor
, Melissa Conrad
, Emmanuel Ruhamyankaka
, Victor Asua
, Andrew Walakira
, Joaniter Nankabirwa
, Adoke Yeka
, Sarah Staedke
, Bryan Greenhouse
, Samuel L. Nsobya
, Moses R. Kamya
, Grant Dorsey
, Philip J. Rosenthal

Infectious Diseases Research Collaboration
Harvard University
Broad Institute
University of California at San Francisco
Makerere University
London School of Hygiene and Tropical Medicine

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	Journal of Infectious Disease
Volume	215
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiw614
Publication status	Published - 15 Feb 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

amodiaquine
artemether
artemisinin
artesunate
chloroquine
dihydroartemisinin
drug resistance
K13
lumefantrine
Malaria
pfcrt
pfmdr1
piperaquine
Plasmodium falciparum

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10.1093/infdis/jiw614

Cite this

Tumwebaze, P., Tukwasibwe, S., Taylor, A., Conrad, M., Ruhamyankaka, E., Asua, V., Walakira, A., Nankabirwa, J., Yeka, A., Staedke, S., Greenhouse, B., Nsobya, S. L., Kamya, M. R., Dorsey, G., & Rosenthal, P. J. (2017). Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. Journal of Infectious Disease, 215(4), 631-635. https://doi.org/10.1093/infdis/jiw614

@article{b6ff7bdbabc7413ab953a61b71802385,

title = "Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda",

abstract = "We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.",

keywords = "amodiaquine, artemether, artemisinin, artesunate, chloroquine, dihydroartemisinin, drug resistance, K13, lumefantrine, Malaria, pfcrt, pfmdr1, piperaquine, Plasmodium falciparum",

author = "Patrick Tumwebaze and Stephen Tukwasibwe and Aimee Taylor and Melissa Conrad and Emmanuel Ruhamyankaka and Victor Asua and Andrew Walakira and Joaniter Nankabirwa and Adoke Yeka and Sarah Staedke and Bryan Greenhouse and Nsobya, \{Samuel L.\} and Kamya, \{Moses R.\} and Grant Dorsey and Rosenthal, \{Philip J.\}",

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doi = "10.1093/infdis/jiw614",

language = "English",

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journal = "Journal of Infectious Disease",

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Tumwebaze, P, Tukwasibwe, S, Taylor, A, Conrad, M, Ruhamyankaka, E, Asua, V, Walakira, A, Nankabirwa, J, Yeka, A, Staedke, S, Greenhouse, B, Nsobya, SL, Kamya, MR, Dorsey, G & Rosenthal, PJ 2017, 'Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda', Journal of Infectious Disease, vol. 215, no. 4, pp. 631-635. https://doi.org/10.1093/infdis/jiw614

TY - JOUR

T1 - Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda

AU - Tumwebaze, Patrick

AU - Tukwasibwe, Stephen

AU - Taylor, Aimee

AU - Conrad, Melissa

AU - Ruhamyankaka, Emmanuel

AU - Asua, Victor

AU - Walakira, Andrew

AU - Nankabirwa, Joaniter

AU - Yeka, Adoke

AU - Staedke, Sarah

AU - Greenhouse, Bryan

AU - Nsobya, Samuel L.

AU - Kamya, Moses R.

AU - Dorsey, Grant

AU - Rosenthal, Philip J.

PY - 2017/2/15

Y1 - 2017/2/15

N2 - We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.

AB - We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.

KW - amodiaquine

KW - artemether

KW - artemisinin

KW - artesunate

KW - chloroquine

KW - dihydroartemisinin

KW - drug resistance

KW - K13

KW - lumefantrine

KW - Malaria

KW - pfcrt

KW - pfmdr1

KW - piperaquine

KW - Plasmodium falciparum

U2 - 10.1093/infdis/jiw614

DO - 10.1093/infdis/jiw614

M3 - Article

VL - 215

SP - 631

EP - 635

JO - Journal of Infectious Disease

JF - Journal of Infectious Disease

IS - 4

ER -

Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda

Abstract

UN SDGs

Keywords

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