Abstract
Cerebral malaria is one of a number of clinical syndromes associated with infection by human malaria parasites of the genus Plasmodium. The etiology of cerebral malaria derives from sequestration of parasitized red cells in brain microvasculature and is thought to be enhanced by the proinflammatory status of the host and virulence characteristics of the infecting parasite variant. In this article we examine the range of factors thought to influence the development of Plasmodium falciparum cerebral malaria in humans and review the evidence to support their role.
| Original language | English |
|---|---|
| Pages (from-to) | 291-302 |
| Number of pages | 12 |
| Journal | Future Microbiology |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cerebralmalaria
- cytoadherence
- immunopathology
- inflammation
- models
- pathogenesis
- PfEMP1
- platelets
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