Cerebral malaria pathogenesis: revisiting parasite and host contributions

Georges Emile Raymond Grau; Alister Craig

doi:10.2217/fmb.11.155

Cerebral malaria pathogenesis: revisiting parasite and host contributions

Georges Emile Raymond Grau, Alister Craig

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

Cerebral malaria is one of a number of clinical syndromes associated with infection by human malaria parasites of the genus Plasmodium. The etiology of cerebral malaria derives from sequestration of parasitized red cells in brain microvasculature and is thought to be enhanced by the proinflammatory status of the host and virulence characteristics of the infecting parasite variant. In this article we examine the range of factors thought to influence the development of Plasmodium falciparum cerebral malaria in humans and review the evidence to support their role.

Original language	English
Pages (from-to)	291-302
Number of pages	12
Journal	Future Microbiology
Volume	7
Issue number	2
DOIs	https://doi.org/10.2217/fmb.11.155
Publication status	Published - 1 Feb 2012

Keywords

cerebralmalaria
cytoadherence
immunopathology
inflammation
models
pathogenesis
PfEMP1
platelets

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fmb.11.155

Cite this

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AB - Cerebral malaria is one of a number of clinical syndromes associated with infection by human malaria parasites of the genus Plasmodium. The etiology of cerebral malaria derives from sequestration of parasitized red cells in brain microvasculature and is thought to be enhanced by the proinflammatory status of the host and virulence characteristics of the infecting parasite variant. In this article we examine the range of factors thought to influence the development of Plasmodium falciparum cerebral malaria in humans and review the evidence to support their role.

KW - cerebralmalaria

KW - cytoadherence

KW - immunopathology

KW - inflammation

KW - models

KW - pathogenesis

KW - PfEMP1

KW - platelets

U2 - 10.2217/fmb.11.155

DO - 10.2217/fmb.11.155

M3 - Review article

SN - 1746-0913

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SP - 291

EP - 302

JO - Future Microbiology

JF - Future Microbiology

IS - 2

ER -

Cerebral malaria pathogenesis: revisiting parasite and host contributions

Abstract

Keywords

UN SDGs

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