Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Hakan Erdem; Derya Ozturk-Engin; Yasemin Cag; Seniha Senbayrak; Asuman Inan; Esra Kazak; Umit Savasci; Nazif Elaldi; Haluk Vahaboglu; Rodrigo Hasbun; Mihai Nechifor; Hulya Tireli; Gamze Kilicoglu; Sylviane Defres; Serda Gulsun; Nurgul Ceran; Alexandru Crisan; Isik Somuncu Johansen; Mustafa Namiduru; Saim Dayan; Uner Kayabas; Emine Parlak; Ahmad Khalifa; Ebru Kursun; Oguz Resat Sipahi; Mucahit Yemisen; Ayhan Akbulut; Mehmet Bitirgen; Natasa Popovic; Bahar Kandemir; Catalina Luca; Mehmet Parlak; Jean Paul Stahl; Filiz Pehlivanoglu; Soline Simeon; Aysegul Ulu-Kilic; Kadriye Yasar; Gulden Yilmaz; Emel Yilmaz; Bojana Beovic; Melanie Catroux; Botond Lakatos; Mustafa Sunbul; Oral Oncul; Selma Alabay; Elif Sahin-Horasan; Sukran Kose; Ghaydaa Shehata; Katell Andre; Gorana Dragovac; Hanefi Cem Gul; Ahmet Karakas; Stéphane Chadapaud; Yves Hansmann; Arjan Harxhi; Valerija Kirova; Isabelle Masse-Chabredier; Serkan Oncu; Alper Sener; Recep Tekin; Ozcan Deveci; Hacer Deniz Ozkaya; Oguz Karabay; Canan Agalar; Serap Gencer; Mustafa Kasim Karahocagil; Hasan Karsen; Selçuk Kaya; Abdullah Umut Pekok; Mustafa Kemal Celen; Secil Deniz; Mehmet Ulug; Tuna Demirdal; Tumer Guven; Sibel Bolukcu; Meltem Avci; Saygin Nayman-Alpat; Kadriye Yaşar; Filiz Pehlivanoʇlu; Selma Ates-Guler; Esmeray Mutlu-Yilmaz; Selma Tosun; Fatma Sirmatel; Ayşe Batirel; Nefise Öztoprak; Ayten Kadanali; Huseyin Turgut; Ali Irfan Baran; Gokhan Karaahmetoglu; Mahmut Sunnetcioglu; Asli Haykir-Solay; Affan Denk; Celal Ayaz; Levent Gorenek; Lykke Larsen; Mario Poljak; Bruno Barsic; Xavier Argemi; Signe Maj Sørensen; Anne Lisbeth Bohr; Pierre Tattevin; Jesper Damsgaard Gunst; Lenka Baštáková; Matjaž Jereb; Mahtab Chehri; Guillaume Beraud; Rosa Fontana Del Vecchio; Mauro Maresca; Hava Yilmaz; Ahmad Sharif-Yakan; Souha Shararah Kanj; Fatime Korkmaz; Suheyla Komur; Seher Ayten Coskuner; Nevin Ince; Yasemin Akkoyunlu; Gulistan Halac; Salih Atakan Nemli; Oznur Ak; Selcuk Kaya; Alper Gunduz; Mustafa G. Gozel; Mustafa Hatipoglu; Gonul Cicek-Senturk; Fusun Z. Akcam; Ahmet C. Inkaya; Ayşe Sagmak-Tartar; Yasemin Ersoy; Gunay Tuncer-Ertem; Ilker I. Balkan; Birsen Cetin; Gulden Ersoz; Nail Ozgunes; Aysegul Yesilkaya; Ayse Erturk; Sibel Gundes; Vedat Turhan; Aysun Yalci; Emsal Aydin; Husrev Diktas; Asim Ulcay; Derya Seyman; Hakan Leblebicioglu

doi:10.1016/j.ijid.2017.10.011

Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Hakan Erdem
, Derya Ozturk-Engin
, Yasemin Cag
, Seniha Senbayrak
, Asuman Inan
, Esra Kazak
, Umit Savasci
, Nazif Elaldi
, Haluk Vahaboglu
, Rodrigo Hasbun
, Mihai Nechifor
, Hulya Tireli
, Gamze Kilicoglu
, Sylviane Defres
, Serda Gulsun
, Nurgul Ceran
, Alexandru Crisan
, Isik Somuncu Johansen
, Mustafa Namiduru
, Saim Dayan

Uner Kayabas, Emine Parlak, Ahmad Khalifa, Ebru Kursun, Oguz Resat Sipahi, Mucahit Yemisen, Ayhan Akbulut, Mehmet Bitirgen, Natasa Popovic, Bahar Kandemir, Catalina Luca, Mehmet Parlak, Jean Paul Stahl, Filiz Pehlivanoglu, Soline Simeon, Aysegul Ulu-Kilic, Kadriye Yasar, Gulden Yilmaz, Emel Yilmaz, Bojana Beovic, Melanie Catroux, Botond Lakatos, Mustafa Sunbul, Oral Oncul, Selma Alabay, Elif Sahin-Horasan, Sukran Kose, Ghaydaa Shehata, Katell Andre, Gorana Dragovac, Hanefi Cem Gul, Ahmet Karakas, Stéphane Chadapaud, Yves Hansmann, Arjan Harxhi, Valerija Kirova, Isabelle Masse-Chabredier, Serkan Oncu, Alper Sener, Recep Tekin, Ozcan Deveci, Hacer Deniz Ozkaya, Oguz Karabay, Canan Agalar, Serap Gencer, Mustafa Kasim Karahocagil, Hasan Karsen, Selçuk Kaya, Abdullah Umut Pekok, Mustafa Kemal Celen, Secil Deniz, Mehmet Ulug, Tuna Demirdal, Tumer Guven, Sibel Bolukcu, Meltem Avci, Saygin Nayman-Alpat, Kadriye Yaşar, Filiz Pehlivanoʇlu, Selma Ates-Guler, Esmeray Mutlu-Yilmaz, Selma Tosun, Fatma Sirmatel, Ayşe Batirel, Nefise Öztoprak, Ayten Kadanali, Huseyin Turgut, Ali Irfan Baran, Gokhan Karaahmetoglu, Mahmut Sunnetcioglu, Asli Haykir-Solay, Affan Denk, Celal Ayaz, Levent Gorenek, Lykke Larsen, Mario Poljak, Bruno Barsic, Xavier Argemi, Signe Maj Sørensen, Anne Lisbeth Bohr, Pierre Tattevin, Jesper Damsgaard Gunst, Lenka Baštáková, Matjaž Jereb, Mahtab Chehri, Guillaume Beraud, Rosa Fontana Del Vecchio, Mauro Maresca, Hava Yilmaz, Ahmad Sharif-Yakan, Souha Shararah Kanj, Fatime Korkmaz, Suheyla Komur, Seher Ayten Coskuner, Nevin Ince, Yasemin Akkoyunlu, Gulistan Halac, Salih Atakan Nemli, Oznur Ak, Selcuk Kaya, Alper Gunduz, Mustafa G. Gozel, Mustafa Hatipoglu, Gonul Cicek-Senturk, Fusun Z. Akcam, Ahmet C. Inkaya, Ayşe Sagmak-Tartar, Yasemin Ersoy, Gunay Tuncer-Ertem, Ilker I. Balkan, Birsen Cetin, Gulden Ersoz, Nail Ozgunes, Aysegul Yesilkaya, Ayse Erturk, Sibel Gundes, Vedat Turhan, Aysun Yalci, Emsal Aydin, Husrev Diktas, Asim Ulcay, Derya Seyman, Hakan Leblebicioglu

Gülhane Military Medical Academy
Haydarpaşa Numune Training and Research Hospital
Ministry of Health, Turkey
Lutfi Kirdar Training and Research Hospital
Uludag University
Cumhuriyet University
University of Texas Health Science Center at Houston
Grigore T. Popa University of Medicine and Pharmacy
Baghdad Medical City
Dr. Fran Mihaljevic University Hospital for Infectious Diseases
University of Liverpool
Liverpool University Hospitals NHS Foundation Trust
Firat University
Diyarbakir Training and Research Hospital
University of Belgrade
Victor Babes University of Medicine and Pharmacy
University of Catania
University of Southern Denmark
Cukurova University
Gaziantep University
Dicle University
Inonu University
Ataturk University
Damascus Hospital
Baskent University
Ege University
Bezmialem Vakif University
Istanbul University - Cerrahpaşa
Necmettin Erbakan University
Clinical Center of Serbia
CHU de Grenoble
Hôpital Pontchaillou
Erciyes University
Ankara University
University Medical Centre Ljubljana
CHU de Poitiers
Szent Lásló Hospital
Ondokuz Mayis University
Mersin University
Tepecik Training and Research Hospital
Assiut University
Dax Hospital
University of Novi Sad
Marie José Treffot Hospital
Hôpitaux Universitaires de Strasbourg
University Medical Center of Tirana "Mother Teresa"
University Clinic for Infectious Diseases and Febrile Conditions
Aurillac Hospital
Adnan Menderes University
Canakkale Onsekiz Mart University
Sakarya University
Fatih Sultan Mehmet Training and Research Hospital
Yuzuncu Yil University
Harran University
Karadeniz Technical University
Department of Infectious Diseases and Clinical Microbiology
Private Umit Hospital
Izmir Katip Celebi University
Atatürk Training and Research Hospital
University of Health Sciences
Osmangazi University
Kahramanmaras Sutcu Imam University
Samsun Research and Training Hospital
Abant Izzet Baysal University
Antalya Training and Research Hospital
Ümraniye Training and Research Hospital
Pamukkale University
Igdir State Hospital
University of Ljubljana
Hôpital civil
Aalborg University
University of Copenhagen
Aarhus University
Masaryk University
American University of Beirut
Konya Meram Training and Research Hospital
Duzce University
Şişli Hamidiye Etfal Training and Research Hospital
Suleyman Demirel University
Hacettepe University
Ankara Numune Education and Research Hospital
Koc University
Recep Tayyip Erdogan University
Kocaeli University
Kafkas University
Military Hospital

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	International Journal of Infectious Diseases
Volume	65
DOIs	https://doi.org/10.1016/j.ijid.2017.10.011
Publication status	Published - 1 Dec 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CSF
Encephalitis
Leukocyte
Meningitis
Pleocytosis

Access to Document

10.1016/j.ijid.2017.10.011Licence: CC BY-NC-ND

Cite this

Erdem, H., Ozturk-Engin, D., Cag, Y., Senbayrak, S., Inan, A., Kazak, E., Savasci, U., Elaldi, N., Vahaboglu, H., Hasbun, R., Nechifor, M., Tireli, H., Kilicoglu, G., Defres, S., Gulsun, S., Ceran, N., Crisan, A., Johansen, I. S., Namiduru, M., ... Leblebicioglu, H. (2017). Central nervous system infections in the absence of cerebrospinal fluid pleocytosis. International Journal of Infectious Diseases, 65, 107-109. https://doi.org/10.1016/j.ijid.2017.10.011

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title = "Central nervous system infections in the absence of cerebrospinal fluid pleocytosis",

abstract = "Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18\% of neurosyphilis, 7.9\% of herpetic meningoencephalitis, 3\% of tuberculous meningitis, 1.7\% of Brucella meningitis, and 0.2\% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.",

keywords = "CSF, Encephalitis, Leukocyte, Meningitis, Pleocytosis",

author = "Hakan Erdem and Derya Ozturk-Engin and Yasemin Cag and Seniha Senbayrak and Asuman Inan and Esra Kazak and Umit Savasci and Nazif Elaldi and Haluk Vahaboglu and Rodrigo Hasbun and Mihai Nechifor and Hulya Tireli and Gamze Kilicoglu and Sylviane Defres and Serda Gulsun and Nurgul Ceran and Alexandru Crisan and Johansen, \{Isik Somuncu\} and Mustafa Namiduru and Saim Dayan and Uner Kayabas and Emine Parlak and Ahmad Khalifa and Ebru Kursun and Sipahi, \{Oguz Resat\} and Mucahit Yemisen and Ayhan Akbulut and Mehmet Bitirgen and Natasa Popovic and Bahar Kandemir and Catalina Luca and Mehmet Parlak and Stahl, \{Jean Paul\} and Filiz Pehlivanoglu and Soline Simeon and Aysegul Ulu-Kilic and Kadriye Yasar and Gulden Yilmaz and Emel Yilmaz and Bojana Beovic and Melanie Catroux and Botond Lakatos and Mustafa Sunbul and Oral Oncul and Selma Alabay and Elif Sahin-Horasan and Sukran Kose and Ghaydaa Shehata and Katell Andre and Gorana Dragovac and Gul, \{Hanefi Cem\} and Ahmet Karakas and St{\'e}phane Chadapaud and Yves Hansmann and Arjan Harxhi and Valerija Kirova and Isabelle Masse-Chabredier and Serkan Oncu and Alper Sener and Recep Tekin and Ozcan Deveci and Ozkaya, \{Hacer Deniz\} and Oguz Karabay and Canan Agalar and Serap Gencer and Karahocagil, \{Mustafa Kasim\} and Hasan Karsen and Sel{\c c}uk Kaya and Pekok, \{Abdullah Umut\} and Celen, \{Mustafa Kemal\} and Secil Deniz and Mehmet Ulug and Tuna Demirdal and Tumer Guven and Sibel Bolukcu and Meltem Avci and Saygin Nayman-Alpat and Kadriye Ya{\c s}ar and Filiz Pehlivanoʇlu and Selma Ates-Guler and Esmeray Mutlu-Yilmaz and Selma Tosun and Fatma Sirmatel and Ay{\c s}e Batirel and Nefise {\"O}ztoprak and Ayten Kadanali and Huseyin Turgut and Baran, \{Ali Irfan\} and Gokhan Karaahmetoglu and Mahmut Sunnetcioglu and Asli Haykir-Solay and Affan Denk and Celal Ayaz and Levent Gorenek and Lykke Larsen and Mario Poljak and Bruno Barsic and Xavier Argemi and S{\o}rensen, \{Signe Maj\} and Bohr, \{Anne Lisbeth\} and Pierre Tattevin and Gunst, \{Jesper Damsgaard\} and Lenka Ba{\v s}t{\'a}kov{\'a} and Matja{\v z} Jereb and Mahtab Chehri and Guillaume Beraud and \{Del Vecchio\}, \{Rosa Fontana\} and Mauro Maresca and Hava Yilmaz and Ahmad Sharif-Yakan and Kanj, \{Souha Shararah\} and Fatime Korkmaz and Suheyla Komur and Coskuner, \{Seher Ayten\} and Nevin Ince and Yasemin Akkoyunlu and Gulistan Halac and Nemli, \{Salih Atakan\} and Oznur Ak and Selcuk Kaya and Alper Gunduz and Gozel, \{Mustafa G.\} and Mustafa Hatipoglu and Gonul Cicek-Senturk and Akcam, \{Fusun Z.\} and Inkaya, \{Ahmet C.\} and Ay{\c s}e Sagmak-Tartar and Yasemin Ersoy and Gunay Tuncer-Ertem and Balkan, \{Ilker I.\} and Birsen Cetin and Gulden Ersoz and Nail Ozgunes and Aysegul Yesilkaya and Ayse Erturk and Sibel Gundes and Vedat Turhan and Aysun Yalci and Emsal Aydin and Husrev Diktas and Asim Ulcay and Derya Seyman and Hakan Leblebicioglu",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.ijid.2017.10.011",

language = "English",

volume = "65",

pages = "107--109",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier B.V.",

}

Erdem, H, Ozturk-Engin, D, Cag, Y, Senbayrak, S, Inan, A, Kazak, E, Savasci, U, Elaldi, N, Vahaboglu, H, Hasbun, R, Nechifor, M, Tireli, H, Kilicoglu, G, Defres, S, Gulsun, S, Ceran, N, Crisan, A, Johansen, IS, Namiduru, M, Dayan, S, Kayabas, U, Parlak, E, Khalifa, A, Kursun, E, Sipahi, OR, Yemisen, M, Akbulut, A, Bitirgen, M, Popovic, N, Kandemir, B, Luca, C, Parlak, M, Stahl, JP, Pehlivanoglu, F, Simeon, S, Ulu-Kilic, A, Yasar, K, Yilmaz, G, Yilmaz, E, Beovic, B, Catroux, M, Lakatos, B, Sunbul, M, Oncul, O, Alabay, S, Sahin-Horasan, E, Kose, S, Shehata, G, Andre, K, Dragovac, G, Gul, HC, Karakas, A, Chadapaud, S, Hansmann, Y, Harxhi, A, Kirova, V, Masse-Chabredier, I, Oncu, S, Sener, A, Tekin, R, Deveci, O, Ozkaya, HD, Karabay, O, Agalar, C, Gencer, S, Karahocagil, MK, Karsen, H, Kaya, S, Pekok, AU, Celen, MK, Deniz, S, Ulug, M, Demirdal, T, Guven, T, Bolukcu, S, Avci, M, Nayman-Alpat, S, Yaşar, K, Pehlivanoʇlu, F, Ates-Guler, S, Mutlu-Yilmaz, E, Tosun, S, Sirmatel, F, Batirel, A, Öztoprak, N, Kadanali, A, Turgut, H, Baran, AI, Karaahmetoglu, G, Sunnetcioglu, M, Haykir-Solay, A, Denk, A, Ayaz, C, Gorenek, L, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, SM, Bohr, AL, Tattevin, P, Gunst, JD, Baštáková, L, Jereb, M, Chehri, M, Beraud, G, Del Vecchio, RF, Maresca, M, Yilmaz, H, Sharif-Yakan, A, Kanj, SS, Korkmaz, F, Komur, S, Coskuner, SA, Ince, N, Akkoyunlu, Y, Halac, G, Nemli, SA, Ak, O, Kaya, S, Gunduz, A, Gozel, MG, Hatipoglu, M, Cicek-Senturk, G, Akcam, FZ, Inkaya, AC, Sagmak-Tartar, A, Ersoy, Y, Tuncer-Ertem, G, Balkan, II, Cetin, B, Ersoz, G, Ozgunes, N, Yesilkaya, A, Erturk, A, Gundes, S, Turhan, V, Yalci, A, Aydin, E, Diktas, H, Ulcay, A, Seyman, D & Leblebicioglu, H 2017, 'Central nervous system infections in the absence of cerebrospinal fluid pleocytosis', International Journal of Infectious Diseases, vol. 65, pp. 107-109. https://doi.org/10.1016/j.ijid.2017.10.011

TY - JOUR

T1 - Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

AU - Erdem, Hakan

AU - Ozturk-Engin, Derya

AU - Cag, Yasemin

AU - Senbayrak, Seniha

AU - Inan, Asuman

AU - Kazak, Esra

AU - Savasci, Umit

AU - Elaldi, Nazif

AU - Vahaboglu, Haluk

AU - Hasbun, Rodrigo

AU - Nechifor, Mihai

AU - Tireli, Hulya

AU - Kilicoglu, Gamze

AU - Defres, Sylviane

AU - Gulsun, Serda

AU - Ceran, Nurgul

AU - Crisan, Alexandru

AU - Johansen, Isik Somuncu

AU - Namiduru, Mustafa

AU - Dayan, Saim

AU - Kayabas, Uner

AU - Parlak, Emine

AU - Khalifa, Ahmad

AU - Kursun, Ebru

AU - Sipahi, Oguz Resat

AU - Yemisen, Mucahit

AU - Akbulut, Ayhan

AU - Bitirgen, Mehmet

AU - Popovic, Natasa

AU - Kandemir, Bahar

AU - Luca, Catalina

AU - Parlak, Mehmet

AU - Stahl, Jean Paul

AU - Pehlivanoglu, Filiz

AU - Simeon, Soline

AU - Ulu-Kilic, Aysegul

AU - Yasar, Kadriye

AU - Yilmaz, Gulden

AU - Yilmaz, Emel

AU - Beovic, Bojana

AU - Catroux, Melanie

AU - Lakatos, Botond

AU - Sunbul, Mustafa

AU - Oncul, Oral

AU - Alabay, Selma

AU - Sahin-Horasan, Elif

AU - Kose, Sukran

AU - Shehata, Ghaydaa

AU - Andre, Katell

AU - Dragovac, Gorana

AU - Gul, Hanefi Cem

AU - Karakas, Ahmet

AU - Chadapaud, Stéphane

AU - Hansmann, Yves

AU - Harxhi, Arjan

AU - Kirova, Valerija

AU - Masse-Chabredier, Isabelle

AU - Oncu, Serkan

AU - Sener, Alper

AU - Tekin, Recep

AU - Deveci, Ozcan

AU - Ozkaya, Hacer Deniz

AU - Karabay, Oguz

AU - Agalar, Canan

AU - Gencer, Serap

AU - Karahocagil, Mustafa Kasim

AU - Karsen, Hasan

AU - Kaya, Selçuk

AU - Pekok, Abdullah Umut

AU - Celen, Mustafa Kemal

AU - Deniz, Secil

AU - Ulug, Mehmet

AU - Demirdal, Tuna

AU - Guven, Tumer

AU - Bolukcu, Sibel

AU - Avci, Meltem

AU - Nayman-Alpat, Saygin

AU - Yaşar, Kadriye

AU - Pehlivanoʇlu, Filiz

AU - Ates-Guler, Selma

AU - Mutlu-Yilmaz, Esmeray

AU - Tosun, Selma

AU - Sirmatel, Fatma

AU - Batirel, Ayşe

AU - Öztoprak, Nefise

AU - Kadanali, Ayten

AU - Turgut, Huseyin

AU - Baran, Ali Irfan

AU - Karaahmetoglu, Gokhan

AU - Sunnetcioglu, Mahmut

AU - Haykir-Solay, Asli

AU - Denk, Affan

AU - Ayaz, Celal

AU - Gorenek, Levent

AU - Larsen, Lykke

AU - Poljak, Mario

AU - Barsic, Bruno

AU - Argemi, Xavier

AU - Sørensen, Signe Maj

AU - Bohr, Anne Lisbeth

AU - Tattevin, Pierre

AU - Gunst, Jesper Damsgaard

AU - Baštáková, Lenka

AU - Jereb, Matjaž

AU - Chehri, Mahtab

AU - Beraud, Guillaume

AU - Del Vecchio, Rosa Fontana

AU - Maresca, Mauro

AU - Yilmaz, Hava

AU - Sharif-Yakan, Ahmad

AU - Kanj, Souha Shararah

AU - Korkmaz, Fatime

AU - Komur, Suheyla

AU - Coskuner, Seher Ayten

AU - Ince, Nevin

AU - Akkoyunlu, Yasemin

AU - Halac, Gulistan

AU - Nemli, Salih Atakan

AU - Ak, Oznur

AU - Kaya, Selcuk

AU - Gunduz, Alper

AU - Gozel, Mustafa G.

AU - Hatipoglu, Mustafa

AU - Cicek-Senturk, Gonul

AU - Akcam, Fusun Z.

AU - Inkaya, Ahmet C.

AU - Sagmak-Tartar, Ayşe

AU - Ersoy, Yasemin

AU - Tuncer-Ertem, Gunay

AU - Balkan, Ilker I.

AU - Cetin, Birsen

AU - Ersoz, Gulden

AU - Ozgunes, Nail

AU - Yesilkaya, Aysegul

AU - Erturk, Ayse

AU - Gundes, Sibel

AU - Turhan, Vedat

AU - Yalci, Aysun

AU - Aydin, Emsal

AU - Diktas, Husrev

AU - Ulcay, Asim

AU - Seyman, Derya

AU - Leblebicioglu, Hakan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

AB - Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

KW - CSF

KW - Encephalitis

KW - Leukocyte

KW - Meningitis

KW - Pleocytosis

U2 - 10.1016/j.ijid.2017.10.011

DO - 10.1016/j.ijid.2017.10.011

M3 - Article

SN - 1201-9712

VL - 65

SP - 107

EP - 109

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Abstract

UN SDGs

Keywords

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