Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

Matthew B. McNeil; Somsundaram Chettiar; Divya Awasthi; Tanya Parish

doi:10.1099/acmi.0.000006

Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

Matthew B. McNeil
, Somsundaram Chettiar
, Divya Awasthi
, Tanya Parish

Infectious Disease Research Institute
University of Otago
TB Discovery Research

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.

Original language	English
Article number	000006
Journal	Access Microbiology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1099/acmi.0.000006
Publication status	Published - 20 Mar 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

mycobacteria
Mycobacterium tuberculosis
permeability
rifampicin
tuberculosis

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10.1099/acmi.0.000006

Cite this

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abstract = "There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.",

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AB - There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.

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KW - Mycobacterium tuberculosis

KW - permeability

KW - rifampicin

KW - tuberculosis

U2 - 10.1099/acmi.0.000006

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ER -

Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

Abstract

UN SDGs

Keywords

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