CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

Tara Stanton; Sally Boxall; Andrea Bennett; Pontiano Kaleebu; Christine Watera; Jimmy Whitworth; Neil French; Ritu Dawes; Adrian V. S. Hill; Walter Bodmer; Peter C. L. Beverley; Elma Z. Tchilian

doi:10.1007/s00251-004-0668-z

CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

Tara Stanton, Sally Boxall, Andrea Bennett, Pontiano Kaleebu, Christine Watera, Jimmy Whitworth, Neil French, Ritu Dawes, Adrian V. S. Hill, Walter Bodmer, Peter C. L. Beverley, Elma Z. Tchilian

Liverpool School of Tropical Medicine

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	Immunogenetics
Volume	56
Issue number	2
DOIs	https://doi.org/10.1007/s00251-004-0668-z
Publication status	Published - 1 May 2004

Keywords

Alternative splicing
CD45
HIV
Polymorphisms
Ugandan

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00251-004-0668-z

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title = "CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans",

abstract = "The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.",

keywords = "Alternative splicing, CD45, HIV, Polymorphisms, Ugandan",

author = "Tara Stanton and Sally Boxall and Andrea Bennett and Pontiano Kaleebu and Christine Watera and Jimmy Whitworth and Neil French and Ritu Dawes and Hill, \{Adrian V. S.\} and Walter Bodmer and Beverley, \{Peter C. L.\} and Tchilian, \{Elma Z.\}",

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doi = "10.1007/s00251-004-0668-z",

language = "English",

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TY - JOUR

T1 - CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

AU - Stanton, Tara

AU - Boxall, Sally

AU - Bennett, Andrea

AU - Kaleebu, Pontiano

AU - Watera, Christine

AU - Whitworth, Jimmy

AU - French, Neil

AU - Dawes, Ritu

AU - Hill, Adrian V. S.

AU - Bodmer, Walter

AU - Beverley, Peter C. L.

AU - Tchilian, Elma Z.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

AB - The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

KW - Alternative splicing

KW - CD45

KW - HIV

KW - Polymorphisms

KW - Ugandan

U2 - 10.1007/s00251-004-0668-z

DO - 10.1007/s00251-004-0668-z

M3 - Article

SN - 0093-7711

VL - 56

SP - 107

EP - 110

JO - Immunogenetics

JF - Immunogenetics

IS - 2

ER -

CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

Abstract

Keywords

UN SDGs

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