Capture of a Novel, Antibiotic Resistance Encoding, Mobile Genetic Element from Escherichia coli Using a New Entrapment Vector

S. Tansirichaiya, S. J. Moyo, M. Al-Haroni, Adam Roberts

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Antimicrobial resistance genes (ARGs) are often associated with mobile genetic elements (MGEs), which facilitate their movement within and between bacterial populations. Detection of mobility is therefore important to understand the dynamics of MGE dissemination and their associated genes, especially in resistant clinical isolates that often have multiple ARGs associated with MGEs. Therefore, this study aimed to develop an entrapment vector to capture active MGEs and ARGs in clinical isolates of Escherichia coli.

Original languageEnglish
Pages (from-to)832-842
Number of pages11
JournalJournal of Applied Microbiology
Volume130
Issue number3
Early online date2 Sept 2020
DOIs
Publication statusPublished - 1 Mar 2021

Keywords

  • antimicrobial resistance
  • clinical isolates
  • entrapment vector
  • insertion sequence
  • mobile genetic element
  • translocatable unit
  • trimethoprim resistance

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