C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia

K. P. Schofield; F. Voulgari; D. I. Gozzard; M. J. Leyland; Nicholas Beeching; J. Stuart

doi:10.1136/jcp.35.8.866

C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia

K. P. Schofield, F. Voulgari, D. I. Gozzard, M. J. Leyland, Nicholas Beeching, J. Stuart

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.

Original language	English
Pages (from-to)	866-869
Number of pages	4
Journal	Journal of Clinical Pathology
Volume	35
Issue number	8
DOIs	https://doi.org/10.1136/jcp.35.8.866
Publication status	Published - 1 Jan 1982
Externally published	Yes

Access to Document

10.1136/jcp.35.8.866

Cite this

@article{5f8cdd7661614d26b145fc53048ea7fb,

title = "C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia",

abstract = "Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.",

author = "Schofield, \{K. P.\} and F. Voulgari and Gozzard, \{D. I.\} and Leyland, \{M. J.\} and Nicholas Beeching and J. Stuart",

year = "1982",

month = jan,

day = "1",

doi = "10.1136/jcp.35.8.866",

language = "English",

volume = "35",

pages = "866--869",

journal = "Journal of Clinical Pathology",

issn = "0021-9746",

publisher = "BMJ Publishing Group",

number = "8",

}

TY - JOUR

T1 - C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia

AU - Schofield, K. P.

AU - Voulgari, F.

AU - Gozzard, D. I.

AU - Leyland, M. J.

AU - Beeching, Nicholas

AU - Stuart, J.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.

AB - Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.

U2 - 10.1136/jcp.35.8.866

DO - 10.1136/jcp.35.8.866

M3 - Article

SN - 0021-9746

VL - 35

SP - 866

EP - 869

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 8

ER -

C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia

Abstract

Access to Document

Fingerprint

Cite this