Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)

B. D. Brooke; G. Kloke; R. H. Hunt; L. L. Koekemoer; E. A. Tem; M. E. Taylor; Graham Small; Janet Hemingway; M. Coetzee

doi:10.1079/ber2001108

Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)

B. D. Brooke
, G. Kloke
, R. H. Hunt
, L. L. Koekemoer
, E. A. Tem
, M. E. Taylor
, Graham Small
, Janet Hemingway
, M. Coetzee

University of the Witwatersrand
Foray Department
Cardiff University

Research output: Contribution to journal › Article › peer-review

184 Citations (Scopus)

Abstract

Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.

Original language	English
Pages (from-to)	265-272
Number of pages	8
Journal	Bulletin of Entomological Research
Volume	91
Issue number	4
DOIs	https://doi.org/10.1079/ber2001108
Publication status	Published - 1 Jan 2001
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1079/ber2001108

Cite this

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title = "Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)",

abstract = "Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.",

author = "Brooke, \{B. D.\} and G. Kloke and Hunt, \{R. H.\} and Koekemoer, \{L. L.\} and Tem, \{E. A.\} and Taylor, \{M. E.\} and Graham Small and Janet Hemingway and M. Coetzee",

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doi = "10.1079/ber2001108",

language = "English",

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T1 - Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)

AU - Brooke, B. D.

AU - Kloke, G.

AU - Hunt, R. H.

AU - Koekemoer, L. L.

AU - Tem, E. A.

AU - Taylor, M. E.

AU - Small, Graham

AU - Hemingway, Janet

AU - Coetzee, M.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.

AB - Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.

U2 - 10.1079/ber2001108

DO - 10.1079/ber2001108

M3 - Article

SN - 0007-4853

VL - 91

SP - 265

EP - 272

JO - Bulletin of Entomological Research

JF - Bulletin of Entomological Research

IS - 4

ER -

Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)

Abstract

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