Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

John Rek; Sara Lynn Blanken; Joseph Okoth; Daniel Ayo; Ismail Onyige; Eric Musasizi; Jordache Ramjith; Chiara Andolina; Kjerstin Lanke; Emmanuel Arinaitwe; Peter Olwoch; Katharine A. Collins; Moses R. Kamya; Grant Dorsey; Chris Drakeley; Sarah Staedke; Teun Bousema; Melissa D. Conrad

doi:10.1093/infdis/jiac169

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

John Rek, Sara Lynn Blanken, Joseph Okoth, Daniel Ayo, Ismail Onyige, Eric Musasizi, Jordache Ramjith, Chiara Andolina, Kjerstin Lanke, Emmanuel Arinaitwe, Peter Olwoch, Katharine A. Collins, Moses R. Kamya, Grant Dorsey, Chris Drakeley, Sarah Staedke, Teun Bousema, Melissa D. Conrad

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32-1.92; P <. 0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3% and 94.7% of the infectious reservoir, respectively. School-aged children (5-15 years old) contributed to 50.4% of transmission events and were important drivers of malaria transmission.

Original language	English
Pages (from-to)	708-713
Number of pages	6
Journal	Journal of Infectious Disease
Volume	226
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiac169
Publication status	Published - 15 Aug 2022
Externally published	Yes

Keywords

gametocytes
malaria transmission
mosquito feeding assays
Plasmodium falciparum
Uganda

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiac169Licence: CC BY-NC-ND

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Rek, J., Blanken, S. L., Okoth, J., Ayo, D., Onyige, I., Musasizi, E., Ramjith, J., Andolina, C., Lanke, K., Arinaitwe, E., Olwoch, P., Collins, K. A., Kamya, M. R., Dorsey, G., Drakeley, C., Staedke, S., Bousema, T., & Conrad, M. D. (2022). Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda. Journal of Infectious Disease, 226(4), 708-713. https://doi.org/10.1093/infdis/jiac169

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title = "Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda",

abstract = "Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95\% CI, 1.32-1.92; P <. 0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3\% and 94.7\% of the infectious reservoir, respectively. School-aged children (5-15 years old) contributed to 50.4\% of transmission events and were important drivers of malaria transmission.",

keywords = "gametocytes, malaria transmission, mosquito feeding assays, Plasmodium falciparum, Uganda",

author = "John Rek and Blanken, \{Sara Lynn\} and Joseph Okoth and Daniel Ayo and Ismail Onyige and Eric Musasizi and Jordache Ramjith and Chiara Andolina and Kjerstin Lanke and Emmanuel Arinaitwe and Peter Olwoch and Collins, \{Katharine A.\} and Kamya, \{Moses R.\} and Grant Dorsey and Chris Drakeley and Sarah Staedke and Teun Bousema and Conrad, \{Melissa D.\}",

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Rek, J, Blanken, SL, Okoth, J, Ayo, D, Onyige, I, Musasizi, E, Ramjith, J, Andolina, C, Lanke, K, Arinaitwe, E, Olwoch, P, Collins, KA, Kamya, MR, Dorsey, G, Drakeley, C, Staedke, S, Bousema, T & Conrad, MD 2022, 'Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda', Journal of Infectious Disease, vol. 226, no. 4, pp. 708-713. https://doi.org/10.1093/infdis/jiac169

TY - JOUR

T1 - Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

AU - Rek, John

AU - Blanken, Sara Lynn

AU - Okoth, Joseph

AU - Ayo, Daniel

AU - Onyige, Ismail

AU - Musasizi, Eric

AU - Ramjith, Jordache

AU - Andolina, Chiara

AU - Lanke, Kjerstin

AU - Arinaitwe, Emmanuel

AU - Olwoch, Peter

AU - Collins, Katharine A.

AU - Kamya, Moses R.

AU - Dorsey, Grant

AU - Drakeley, Chris

AU - Staedke, Sarah

AU - Bousema, Teun

AU - Conrad, Melissa D.

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32-1.92; P <. 0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3% and 94.7% of the infectious reservoir, respectively. School-aged children (5-15 years old) contributed to 50.4% of transmission events and were important drivers of malaria transmission.

AB - Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32-1.92; P <. 0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3% and 94.7% of the infectious reservoir, respectively. School-aged children (5-15 years old) contributed to 50.4% of transmission events and were important drivers of malaria transmission.

KW - gametocytes

KW - malaria transmission

KW - mosquito feeding assays

KW - Plasmodium falciparum

KW - Uganda

U2 - 10.1093/infdis/jiac169

DO - 10.1093/infdis/jiac169

M3 - Article

VL - 226

SP - 708

EP - 713

JO - Journal of Infectious Disease

JF - Journal of Infectious Disease

IS - 4

ER -

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Abstract

Keywords

UN SDGs

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