Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Kathryn Chu; Sukhum Jiamton; Jacques Pepin; Frances Cowan; Bussakorn Mahakkanukrauh; Ruengpung Suttent; Noah J. Robinson; Sylvie Deslandes; Eric Frost; Pongsakdi Chaisilwattana; Puan Suthipinittharm; Heiner Grosskurth; David Brown; Shabbar Jaffar

doi:10.1258/095646206780071108

Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Kathryn Chu, Sukhum Jiamton, Jacques Pepin, Frances Cowan, Bussakorn Mahakkanukrauh, Ruengpung Suttent, Noah J. Robinson, Sylvie Deslandes, Eric Frost, Pongsakdi Chaisilwattana, Puan Suthipinittharm, Heiner Grosskurth, David Brown, Shabbar Jaffar

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.

Original language	English
Pages (from-to)	681-686
Number of pages	6
Journal	International Journal of Std & Aids
Volume	17
Issue number	10
DOIs	https://doi.org/10.1258/095646206780071108
Publication status	Published - 1 Jan 2006
Externally published	Yes

Keywords

HIV-1
HSV-2
Thailand
Viral load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1258/095646206780071108

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Chu, K., Jiamton, S., Pepin, J., Cowan, F., Mahakkanukrauh, B., Suttent, R., Robinson, N. J., Deslandes, S., Frost, E., Chaisilwattana, P., Suthipinittharm, P., Grosskurth, H., Brown, D., & Jaffar, S. (2006). Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women. International Journal of Std & Aids, 17(10), 681-686. https://doi.org/10.1258/095646206780071108

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title = "Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women",

abstract = "We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68\%) men and 57 (80\%) women were HSV-2 antibody positive, of whom 12 (26\%, 95\% confidence interval [CI] 20, 32) and five (8\%, 95\% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95\% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.",

keywords = "HIV-1, HSV-2, Thailand, Viral load",

author = "Kathryn Chu and Sukhum Jiamton and Jacques Pepin and Frances Cowan and Bussakorn Mahakkanukrauh and Ruengpung Suttent and Robinson, \{Noah J.\} and Sylvie Deslandes and Eric Frost and Pongsakdi Chaisilwattana and Puan Suthipinittharm and Heiner Grosskurth and David Brown and Shabbar Jaffar",

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Chu, K, Jiamton, S, Pepin, J, Cowan, F, Mahakkanukrauh, B, Suttent, R, Robinson, NJ, Deslandes, S, Frost, E, Chaisilwattana, P, Suthipinittharm, P, Grosskurth, H, Brown, D & Jaffar, S 2006, 'Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women', International Journal of Std & Aids, vol. 17, no. 10, pp. 681-686. https://doi.org/10.1258/095646206780071108

TY - JOUR

T1 - Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

AU - Chu, Kathryn

AU - Jiamton, Sukhum

AU - Pepin, Jacques

AU - Cowan, Frances

AU - Mahakkanukrauh, Bussakorn

AU - Suttent, Ruengpung

AU - Robinson, Noah J.

AU - Deslandes, Sylvie

AU - Frost, Eric

AU - Chaisilwattana, Pongsakdi

AU - Suthipinittharm, Puan

AU - Grosskurth, Heiner

AU - Brown, David

AU - Jaffar, Shabbar

PY - 2006/1/1

Y1 - 2006/1/1

N2 - We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.

AB - We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.

KW - HIV-1

KW - HSV-2

KW - Thailand

KW - Viral load

U2 - 10.1258/095646206780071108

DO - 10.1258/095646206780071108

M3 - Article

VL - 17

SP - 681

EP - 686

JO - International Journal of Std & Aids

JF - International Journal of Std & Aids

IS - 10

ER -

Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Abstract

Keywords

UN SDGs

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