Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Kristina E.N. Clark; William Nevin; Tabitha Mahungu; Helen Lachmann; Animesh Singh

doi:10.1093/cid/ciaa1463

Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Kristina E.N. Clark, William Nevin, Tabitha Mahungu, Helen Lachmann, Animesh Singh

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.

Original language	English
Pages (from-to)	E3110-E3112
Journal	Clinical Infectious Diseases
Volume	73
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciaa1463
Publication status	Published - 1 Nov 2021
Externally published	Yes

Keywords

COVID-19
cytokine storm
HLH
HScore

Access to Document

10.1093/cid/ciaa1463

Infectious diseases in at-risk UK Armed Forces populations, with a focus on gastrointestinal parasite infections and Staphylococcus aureus carriage
Nevin, W. (Author), Fletcher, T. (Supervisor), Beeching, N. (Supervisor), Lamb, L. E. (Supervisor) & O'Shea, M. K. (Supervisor), 30 Oct 2025
Student thesis: Doctoral thesis

Cite this

@article{2e0ffd52b06d44cd8446fb93f1861a08,

title = "Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019",

abstract = "The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.",

keywords = "COVID-19, cytokine storm, HLH, HScore",

author = "Clark, \{Kristina E.N.\} and William Nevin and Tabitha Mahungu and Helen Lachmann and Animesh Singh",

year = "2021",

month = nov,

day = "1",

doi = "10.1093/cid/ciaa1463",

language = "English",

volume = "73",

pages = "E3110--E3112",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

AU - Clark, Kristina E.N.

AU - Nevin, William

AU - Mahungu, Tabitha

AU - Lachmann, Helen

AU - Singh, Animesh

PY - 2021/11/1

Y1 - 2021/11/1

N2 - The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.

AB - The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.

KW - COVID-19

KW - cytokine storm

KW - HLH

KW - HScore

U2 - 10.1093/cid/ciaa1463

DO - 10.1093/cid/ciaa1463

M3 - Article

SN - 1058-4838

VL - 73

SP - E3110-E3112

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Abstract

Keywords

Access to Document

Fingerprint

Student theses

Infectious diseases in at-risk UK Armed Forces populations, with a focus on gastrointestinal parasite infections and Staphylococcus aureus carriage

Cite this