Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Kristina E.N. Clark; William Nevin; Tabitha Mahungu; Helen Lachmann; Animesh Singh

doi:10.1093/cid/ciaa1463

Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Kristina E.N. Clark, William Nevin, Tabitha Mahungu, Helen Lachmann, Animesh Singh

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.

Original language	English
Pages (from-to)	E3110-E3112
Journal	Clinical Infectious Diseases
Volume	73
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciaa1463
Publication status	Published - 1 Nov 2021
Externally published	Yes

Keywords

COVID-19
cytokine storm
HLH
HScore

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10.1093/cid/ciaa1463

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title = "Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019",

abstract = "The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.",

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AU - Singh, Animesh

PY - 2021/11/1

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AB - The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.

KW - COVID-19

KW - cytokine storm

KW - HLH

KW - HScore

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DO - 10.1093/cid/ciaa1463

M3 - Article

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

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Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients with Coronavirus Disease 2019

Abstract

Keywords

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