Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Louise LaPensée; Sunil Sabbani; Raman Sharma; Inder Bhamra; Emma Shore; Amy E. Chadwick; Neil G. Berry; James Firman; Nuna C. Araujo; Lília Cabral; Maria L.S. Cristiano; Cerys Bateman; Omar Janneh; Adelina Gavrila; Yi Hang Wu; Afthab Hussain; Steve Ward; Paul A. Stocks; Rick Cosstick; Paul M. O'Neill

doi:10.1002/cmdc.201200536

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Louise LaPensée
, Sunil Sabbani
, Raman Sharma
, Inder Bhamra
, Emma Shore
, Amy E. Chadwick
, Neil G. Berry
, James Firman
, Nuna C. Araujo
, Lília Cabral
, Maria L.S. Cristiano
, Cerys Bateman
, Omar Janneh
, Adelina Gavrila
, Yi Hang Wu
, Afthab Hussain
, Steve Ward
, Paul A. Stocks
, Rick Cosstick
, Paul M. O'Neill

Tropical Disease Biology

University of Liverpool
University of Algarve
Coventry University
Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

Original language	English
Pages (from-to)	709-718
Number of pages	10
Journal	ChemMedChem
Volume	8
Issue number	5
DOIs	https://doi.org/10.1002/cmdc.201200536
Publication status	Published - 1 May 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Artemisinin
Binding studies
Cytotoxicity
DNA
Molecular modelling

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10.1002/cmdc.201200536

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LaPensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., Berry, N. G., Firman, J., Araujo, N. C., Cabral, L., Cristiano, M. L. S., Bateman, C., Janneh, O., Gavrila, A., Wu, Y. H., Hussain, A., Ward, S., Stocks, P. A., Cosstick, R., & O'Neill, P. M. (2013). Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, 8(5), 709-718. https://doi.org/10.1002/cmdc.201200536

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title = "Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.",

abstract = "Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.",

keywords = "Artemisinin, Binding studies, Cytotoxicity, DNA, Molecular modelling",

author = "Louise LaPens{\'e}e and Sunil Sabbani and Raman Sharma and Inder Bhamra and Emma Shore and Chadwick, \{Amy E.\} and Berry, \{Neil G.\} and James Firman and Araujo, \{Nuna C.\} and L{\'i}lia Cabral and Cristiano, \{Maria L.S.\} and Cerys Bateman and Omar Janneh and Adelina Gavrila and Wu, \{Yi Hang\} and Afthab Hussain and Steve Ward and Stocks, \{Paul A.\} and Rick Cosstick and O'Neill, \{Paul M.\}",

year = "2013",

month = may,

day = "1",

doi = "10.1002/cmdc.201200536",

language = "English",

volume = "8",

pages = "709--718",

journal = "ChemMedChem",

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publisher = "John Wiley and Sons Ltd",

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LaPensée, L, Sabbani, S, Sharma, R, Bhamra, I, Shore, E, Chadwick, AE, Berry, NG, Firman, J, Araujo, NC, Cabral, L, Cristiano, MLS, Bateman, C, Janneh, O, Gavrila, A, Wu, YH, Hussain, A, Ward, S, Stocks, PA, Cosstick, R & O'Neill, PM 2013, 'Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.', ChemMedChem, vol. 8, no. 5, pp. 709-718. https://doi.org/10.1002/cmdc.201200536

TY - JOUR

T1 - Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

AU - LaPensée, Louise

AU - Sabbani, Sunil

AU - Sharma, Raman

AU - Bhamra, Inder

AU - Shore, Emma

AU - Chadwick, Amy E.

AU - Berry, Neil G.

AU - Firman, James

AU - Araujo, Nuna C.

AU - Cabral, Lília

AU - Cristiano, Maria L.S.

AU - Bateman, Cerys

AU - Janneh, Omar

AU - Gavrila, Adelina

AU - Wu, Yi Hang

AU - Hussain, Afthab

AU - Ward, Steve

AU - Stocks, Paul A.

AU - Cosstick, Rick

AU - O'Neill, Paul M.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

AB - Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

KW - Artemisinin

KW - Binding studies

KW - Cytotoxicity

KW - DNA

KW - Molecular modelling

U2 - 10.1002/cmdc.201200536

DO - 10.1002/cmdc.201200536

M3 - Article

SN - 1860-7179

VL - 8

SP - 709

EP - 718

JO - ChemMedChem

JF - ChemMedChem

IS - 5

ER -

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Abstract

UN SDGs

Keywords

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