Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Louise LaPensée; Sunil Sabbani; Raman Sharma; Inder Bhamra; Emma Shore; Amy E. Chadwick; Neil G. Berry; James Firman; Nuna C. Araujo; Lília Cabral; Maria L.S. Cristiano; Cerys Bateman; Omar Janneh; Adelina Gavrila; Yi Hang Wu; Afthab Hussain; Steve Ward; Paul A. Stocks; Rick Cosstick; Paul M. O'Neill

doi:10.1002/cmdc.201200536

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Louise LaPensée, Sunil Sabbani, Raman Sharma, Inder Bhamra, Emma Shore, Amy E. Chadwick, Neil G. Berry, James Firman, Nuna C. Araujo, Lília Cabral, Maria L.S. Cristiano, Cerys Bateman, Omar Janneh, Adelina Gavrila, Yi Hang Wu, Afthab Hussain, Steve Ward, Paul A. Stocks, Rick Cosstick, Paul M. O'Neill

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

Original language	English
Pages (from-to)	709-718
Number of pages	10
Journal	ChemMedChem
Volume	8
Issue number	5
DOIs	https://doi.org/10.1002/cmdc.201200536
Publication status	Published - 1 May 2013

Keywords

Artemisinin
Binding studies
Cytotoxicity
DNA
Molecular modelling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cmdc.201200536

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LaPensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., Berry, N. G., Firman, J., Araujo, N. C., Cabral, L., Cristiano, M. L. S., Bateman, C., Janneh, O., Gavrila, A., Wu, Y. H., Hussain, A., Ward, S., Stocks, P. A., Cosstick, R., & O'Neill, P. M. (2013). Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation. ChemMedChem, 8(5), 709-718. https://doi.org/10.1002/cmdc.201200536

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title = "Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.",

abstract = "Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.",

keywords = "Artemisinin, Binding studies, Cytotoxicity, DNA, Molecular modelling",

author = "Louise LaPens{\'e}e and Sunil Sabbani and Raman Sharma and Inder Bhamra and Emma Shore and Chadwick, \{Amy E.\} and Berry, \{Neil G.\} and James Firman and Araujo, \{Nuna C.\} and L{\'i}lia Cabral and Cristiano, \{Maria L.S.\} and Cerys Bateman and Omar Janneh and Adelina Gavrila and Wu, \{Yi Hang\} and Afthab Hussain and Steve Ward and Stocks, \{Paul A.\} and Rick Cosstick and O'Neill, \{Paul M.\}",

year = "2013",

month = may,

day = "1",

doi = "10.1002/cmdc.201200536",

language = "English",

volume = "8",

pages = "709--718",

journal = "ChemMedChem",

issn = "1860-7179",

publisher = "John Wiley and Sons Ltd",

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}

LaPensée, L, Sabbani, S, Sharma, R, Bhamra, I, Shore, E, Chadwick, AE, Berry, NG, Firman, J, Araujo, NC, Cabral, L, Cristiano, MLS, Bateman, C, Janneh, O, Gavrila, A, Wu, YH, Hussain, A, Ward, S, Stocks, PA, Cosstick, R & O'Neill, PM 2013, 'Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.', ChemMedChem, vol. 8, no. 5, pp. 709-718. https://doi.org/10.1002/cmdc.201200536

TY - JOUR

T1 - Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

AU - LaPensée, Louise

AU - Sabbani, Sunil

AU - Sharma, Raman

AU - Bhamra, Inder

AU - Shore, Emma

AU - Chadwick, Amy E.

AU - Berry, Neil G.

AU - Firman, James

AU - Araujo, Nuna C.

AU - Cabral, Lília

AU - Cristiano, Maria L.S.

AU - Bateman, Cerys

AU - Janneh, Omar

AU - Gavrila, Adelina

AU - Wu, Yi Hang

AU - Hussain, Afthab

AU - Ward, Steve

AU - Stocks, Paul A.

AU - Cosstick, Rick

AU - O'Neill, Paul M.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

AB - Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.

KW - Artemisinin

KW - Binding studies

KW - Cytotoxicity

KW - DNA

KW - Molecular modelling

U2 - 10.1002/cmdc.201200536

DO - 10.1002/cmdc.201200536

M3 - Article

SN - 1860-7179

VL - 8

SP - 709

EP - 718

JO - ChemMedChem

JF - ChemMedChem

IS - 5

ER -

Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.

Abstract

Keywords

UN SDGs

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