Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton; Anthony Payton; Eelke H. van den Boogerd; Fiona Holland; Peter Diggle; Patrick M.A. Rabbitt; Michael A. Horan; Jane Worthington; William E.R. Ollier

doi:10.1016/s0304-3940(02)00135-0

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton, Anthony Payton, Eelke H. van den Boogerd, Fiona Holland, Peter Diggle, Patrick M.A. Rabbitt, Michael A. Horan, Jane Worthington, William E.R. Ollier

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Abstract

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Neuroscience Letters
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/s0304-3940(02)00135-0
Publication status	Published - 10 May 2002
Externally published	Yes

Keywords

Aged
Apolipoprotein E
Genetics
Intelligence

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10.1016/s0304-3940(02)00135-0

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title = "Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults",

abstract = "There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.",

keywords = "Aged, Apolipoprotein E, Genetics, Intelligence",

author = "Neil Pendleton and Anthony Payton and \{van den Boogerd\}, \{Eelke H.\} and Fiona Holland and Peter Diggle and Rabbitt, \{Patrick M.A.\} and Horan, \{Michael A.\} and Jane Worthington and Ollier, \{William E.R.\}",

year = "2002",

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doi = "10.1016/s0304-3940(02)00135-0",

language = "English",

volume = "324",

pages = "74--76",

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T1 - Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

AU - Pendleton, Neil

AU - Payton, Anthony

AU - van den Boogerd, Eelke H.

AU - Holland, Fiona

AU - Diggle, Peter

AU - Rabbitt, Patrick M.A.

AU - Horan, Michael A.

AU - Worthington, Jane

AU - Ollier, William E.R.

PY - 2002/5/10

Y1 - 2002/5/10

N2 - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

AB - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

KW - Aged

KW - Apolipoprotein E

KW - Genetics

KW - Intelligence

U2 - 10.1016/s0304-3940(02)00135-0

DO - 10.1016/s0304-3940(02)00135-0

M3 - Article

SN - 0304-3940

VL - 324

SP - 74

EP - 76

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Abstract

Keywords

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