Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton; Anthony Payton; Eelke H. van den Boogerd; Fiona Holland; Peter Diggle; Patrick M.A. Rabbitt; Michael A. Horan; Jane Worthington; William E.R. Ollier

doi:10.1016/s0304-3940(02)00135-0

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton
, Anthony Payton
, Eelke H. van den Boogerd
, Fiona Holland
, Peter Diggle
, Patrick M.A. Rabbitt
, Michael A. Horan
, Jane Worthington
, William E.R. Ollier

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Neuroscience Letters
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/s0304-3940(02)00135-0
Publication status	Published - 10 May 2002
Externally published	Yes

Keywords

Aged
Apolipoprotein E
Genetics
Intelligence

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10.1016/s0304-3940(02)00135-0

Cite this

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title = "Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults",

abstract = "There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.",

keywords = "Aged, Apolipoprotein E, Genetics, Intelligence",

author = "Neil Pendleton and Anthony Payton and \{van den Boogerd\}, \{Eelke H.\} and Fiona Holland and Peter Diggle and Rabbitt, \{Patrick M.A.\} and Horan, \{Michael A.\} and Jane Worthington and Ollier, \{William E.R.\}",

year = "2002",

month = may,

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doi = "10.1016/s0304-3940(02)00135-0",

language = "English",

volume = "324",

pages = "74--76",

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TY - JOUR

T1 - Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

AU - Pendleton, Neil

AU - Payton, Anthony

AU - van den Boogerd, Eelke H.

AU - Holland, Fiona

AU - Diggle, Peter

AU - Rabbitt, Patrick M.A.

AU - Horan, Michael A.

AU - Worthington, Jane

AU - Ollier, William E.R.

PY - 2002/5/10

Y1 - 2002/5/10

N2 - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

AB - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

KW - Aged

KW - Apolipoprotein E

KW - Genetics

KW - Intelligence

U2 - 10.1016/s0304-3940(02)00135-0

DO - 10.1016/s0304-3940(02)00135-0

M3 - Article

SN - 0304-3940

VL - 324

SP - 74

EP - 76

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Abstract

Keywords

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