Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection

Mark A. Ellul; Michael J. Griffiths; Anand Iyer; Shivaram Avula; Sylviane Defres; Atik Baborie; Angela Vincent; Natalie G. Martin; Manish Sadarangani; Andrew J. Pollard; Tom Solomon; Rachel Kneen

doi:10.1097/inf.0000000000001011

Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection

Mark A. Ellul
, Michael J. Griffiths
, Anand Iyer
, Shivaram Avula
, Sylviane Defres
, Atik Baborie
, Angela Vincent
, Natalie G. Martin
, Manish Sadarangani
, Andrew J. Pollard
, Tom Solomon
, Rachel Kneen

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We report a 3-year-old boy with anti-N-methyl-d-aspartate receptor encephalitis with a typical syndrome of movement disorder and encephalopathy and evidence of herpes simplex virus (HSV) type 1 infection on brain biopsy. HSV type 1 infection and anti-N-methyl-d-aspartate receptor encephalitis are temporally linked in some cases: this case suggests that prodromal HSV type-1 infection may be clinically subtle and easily missed.

Original language	English
Pages (from-to)	347-349
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	35
Issue number	3
DOIs	https://doi.org/10.1097/inf.0000000000001011
Publication status	Published - 1 Mar 2016
Externally published	Yes

Keywords

Autoantibody
Encephalitis
Encephalopathy
Herpes simplex virus
N-methyl-d-aspartate receptor

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10.1097/inf.0000000000001011

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Ellul, M. A., Griffiths, M. J., Iyer, A., Avula, S., Defres, S., Baborie, A., Vincent, A., Martin, N. G., Sadarangani, M., Pollard, A. J., Solomon, T., & Kneen, R. (2016). Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection. Pediatric Infectious Disease Journal, 35(3), 347-349. https://doi.org/10.1097/inf.0000000000001011

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title = "Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection",

abstract = "We report a 3-year-old boy with anti-N-methyl-d-aspartate receptor encephalitis with a typical syndrome of movement disorder and encephalopathy and evidence of herpes simplex virus (HSV) type 1 infection on brain biopsy. HSV type 1 infection and anti-N-methyl-d-aspartate receptor encephalitis are temporally linked in some cases: this case suggests that prodromal HSV type-1 infection may be clinically subtle and easily missed.",

keywords = "Autoantibody, Encephalitis, Encephalopathy, Herpes simplex virus, N-methyl-d-aspartate receptor",

author = "Ellul, \{Mark A.\} and Griffiths, \{Michael J.\} and Anand Iyer and Shivaram Avula and Sylviane Defres and Atik Baborie and Angela Vincent and Martin, \{Natalie G.\} and Manish Sadarangani and Pollard, \{Andrew J.\} and Tom Solomon and Rachel Kneen",

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month = mar,

day = "1",

doi = "10.1097/inf.0000000000001011",

language = "English",

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pages = "347--349",

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Ellul, MA, Griffiths, MJ, Iyer, A, Avula, S, Defres, S, Baborie, A, Vincent, A, Martin, NG, Sadarangani, M, Pollard, AJ, Solomon, T & Kneen, R 2016, 'Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection', Pediatric Infectious Disease Journal, vol. 35, no. 3, pp. 347-349. https://doi.org/10.1097/inf.0000000000001011

Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection. / Ellul, Mark A.; Griffiths, Michael J.; Iyer, Anand et al.
In: Pediatric Infectious Disease Journal, Vol. 35, No. 3, 01.03.2016, p. 347-349.

Research output: Contribution to journal › Article › peer-review

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T1 - Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection

AU - Ellul, Mark A.

AU - Griffiths, Michael J.

AU - Iyer, Anand

AU - Avula, Shivaram

AU - Defres, Sylviane

AU - Baborie, Atik

AU - Vincent, Angela

AU - Martin, Natalie G.

AU - Sadarangani, Manish

AU - Pollard, Andrew J.

AU - Solomon, Tom

AU - Kneen, Rachel

PY - 2016/3/1

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AB - We report a 3-year-old boy with anti-N-methyl-d-aspartate receptor encephalitis with a typical syndrome of movement disorder and encephalopathy and evidence of herpes simplex virus (HSV) type 1 infection on brain biopsy. HSV type 1 infection and anti-N-methyl-d-aspartate receptor encephalitis are temporally linked in some cases: this case suggests that prodromal HSV type-1 infection may be clinically subtle and easily missed.

KW - Autoantibody

KW - Encephalitis

KW - Encephalopathy

KW - Herpes simplex virus

KW - N-methyl-d-aspartate receptor

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DO - 10.1097/inf.0000000000001011

M3 - Article

SN - 0891-3668

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JF - Pediatric Infectious Disease Journal

IS - 3

ER -

Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection

Abstract

Keywords

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