Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.

Nadia Kontogianni; Daisy Bengey; Dom Wooding; Katie Buist; Caitlin Greenland-Bews; Chris Williams; Margaretha de Vos; Victor Santana Santos; Camille Escadafal; Emily Adams; Thomas Edwards; Ana Isabel Cubas-Atienzar

doi:10.1590/0037-8682-0016-2022

Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.

Nadia Kontogianni, Daisy Bengey, Dom Wooding, Katie Buist, Caitlin Greenland-Bews, Chris Williams, Margaretha de Vos, Victor Santana Santos, Camille Escadafal, Emily Adams, Thomas Edwards, Ana Isabel Cubas-Atienzar

Research output: Contribution to journal › Article › peer-review

Abstract

Background:

The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.

Methods:

Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant.

Results:

Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.

Conclusions:

This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.

Original language	English
Article number	e0016-2022
Pages (from-to)	e0016
Journal	Revista da Sociedade Brasileira de Medicina Tropical
Volume	55
DOIs	https://doi.org/10.1590/0037-8682-0016-2022
Publication status	Published - 6 Jun 2022

Keywords

Diagnostic tests
SARS-CoV-2
SARS-CoV-2 Gamma variant
Variant of concern

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10.1590/0037-8682-0016-2022Licence: CC BY

Revista brasil med trop 55 e0016-2022Final published version, 492 KBLicence: CC BY

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Kontogianni, N., Bengey, D., Wooding, D., Buist, K., Greenland-Bews, C., Williams, C., de Vos, M., Santos, V. S., Escadafal, C., Adams, E., Edwards, T., & Cubas-Atienzar, A. I. (2022). Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage. Revista da Sociedade Brasileira de Medicina Tropical, 55, e0016. Article e0016-2022. https://doi.org/10.1590/0037-8682-0016-2022

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title = "Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.",

abstract = "Background:The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.Methods:Ag-RDTs were performed according to the manufacturer{\textquoteright}s instructions with a clinical isolate of the Gamma variant.Results:Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.Conclusions:This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.",

keywords = "Diagnostic tests, SARS-CoV-2, SARS-CoV-2 Gamma variant, Variant of concern",

author = "Nadia Kontogianni and Daisy Bengey and Dom Wooding and Katie Buist and Caitlin Greenland-Bews and Chris Williams and \{de Vos\}, Margaretha and Santos, \{Victor Santana\} and Camille Escadafal and Emily Adams and Thomas Edwards and Cubas-Atienzar, \{Ana Isabel\}",

year = "2022",

month = jun,

day = "6",

doi = "10.1590/0037-8682-0016-2022",

language = "English",

volume = "55",

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Kontogianni, N, Bengey, D, Wooding, D, Buist, K, Greenland-Bews, C , Williams, C, de Vos, M, Santos, VS, Escadafal, C, Adams, E, Edwards, T & Cubas-Atienzar, AI 2022, 'Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.', Revista da Sociedade Brasileira de Medicina Tropical, vol. 55, e0016-2022, pp. e0016. https://doi.org/10.1590/0037-8682-0016-2022

Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage. / Kontogianni, Nadia; Bengey, Daisy; Wooding, Dom et al.
In: Revista da Sociedade Brasileira de Medicina Tropical, Vol. 55, e0016-2022, 06.06.2022, p. e0016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.

AU - Kontogianni, Nadia

AU - Bengey, Daisy

AU - Wooding, Dom

AU - Buist, Katie

AU - Greenland-Bews, Caitlin

AU - Williams, Chris

AU - de Vos, Margaretha

AU - Santos, Victor Santana

AU - Escadafal, Camille

AU - Adams, Emily

AU - Edwards, Thomas

AU - Cubas-Atienzar, Ana Isabel

PY - 2022/6/6

Y1 - 2022/6/6

N2 - Background:The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.Methods:Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant.Results:Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.Conclusions:This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.

AB - Background:The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.Methods:Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant.Results:Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.Conclusions:This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.

KW - Diagnostic tests

KW - SARS-CoV-2

KW - SARS-CoV-2 Gamma variant

KW - Variant of concern

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DO - 10.1590/0037-8682-0016-2022

M3 - Article

SN - 0037-8682

VL - 55

SP - e0016

JO - Revista da Sociedade Brasileira de Medicina Tropical

JF - Revista da Sociedade Brasileira de Medicina Tropical

M1 - e0016-2022

ER -

Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.

Abstract

Keywords

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