An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey

Jorge Cano; Paula Moraga; Birgit Nikolay; Maria P. Rebollo; Patricia N. Okorie; Emmanuel Davies; Sammy M. Njenga; Moses Bockarie; Simon J. Brooker

doi:10.1093/trstmh/trv048

An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey

Jorge Cano
, Paula Moraga
, Birgit Nikolay
, Maria P. Rebollo
, Patricia N. Okorie
, Emmanuel Davies
, Sammy M. Njenga
, Moses Bockarie
, Simon J. Brooker

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background

The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.

Methods

This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.

Results and Conclusions

In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

Original language	English
Pages (from-to)	529-531
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	109
Issue number	8
DOIs	https://doi.org/10.1093/trstmh/trv048
Publication status	Published - 21 Jun 2015

Keywords

Antigenaemia
Logistic regression
Lymphatic filariasis
Microfilaraemia
Prevalence surveys

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10.1093/trstmh/trv048Licence: CC BY

Trans R Soc Trop Med Hyg 109 8 529-531Final published version, 233 KBLicence: CC BY

Cite this

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title = "An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey",

abstract = "Background The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.Methods This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.Results and Conclusions In some settings there was a very large disparity, up to 40–70\%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.",

keywords = "Antigenaemia, Logistic regression, Lymphatic filariasis, Microfilaraemia, Prevalence surveys",

author = "Jorge Cano and Paula Moraga and Birgit Nikolay and Rebollo, \{Maria P.\} and Okorie, \{Patricia N.\} and Emmanuel Davies and Njenga, \{Sammy M.\} and Moses Bockarie and Brooker, \{Simon J.\}",

year = "2015",

month = jun,

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doi = "10.1093/trstmh/trv048",

language = "English",

volume = "109",

pages = "529--531",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

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TY - JOUR

T1 - An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey

AU - Cano, Jorge

AU - Moraga, Paula

AU - Nikolay, Birgit

AU - Rebollo, Maria P.

AU - Okorie, Patricia N.

AU - Davies, Emmanuel

AU - Njenga, Sammy M.

AU - Bockarie, Moses

AU - Brooker, Simon J.

PY - 2015/6/21

Y1 - 2015/6/21

N2 - Background The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.Methods This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.Results and Conclusions In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

AB - Background The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.Methods This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.Results and Conclusions In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

KW - Antigenaemia

KW - Logistic regression

KW - Lymphatic filariasis

KW - Microfilaraemia

KW - Prevalence surveys

U2 - 10.1093/trstmh/trv048

DO - 10.1093/trstmh/trv048

M3 - Article

SN - 0035-9203

VL - 109

SP - 529

EP - 531

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 8

ER -

An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey

Abstract

Keywords

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