TY - JOUR
T1 - Aetiologies of central nervous system infection in Viet Nam: A prospective provincial hospital-based descriptive surveillance study: A prospective provincial hospital-based descriptive surveillance study
AU - Ho Dang Trung, Nghia
AU - Le Thi Phuong, Tu
AU - Wolbers, Marcel
AU - Nguyen van Minh, Hoang
AU - Nguyen Thanh, Vinh
AU - Van, Minh Pham
AU - Thieu, Nga Tran Vu
AU - Le Van, Tan
AU - Song, Diep To
AU - Le Thi, Phuong
AU - Thi Phuong, Thao Nguyen
AU - Van, Cong Bui
AU - Tang, Vu
AU - Ngoc Anh, Tuan Hoang
AU - Nguyen, Dong
AU - Trung, Tien Phan
AU - Thi Nam, Lien Nguyen
AU - Kiem, Hao Tran
AU - Thi Thanh, Tam Nguyen
AU - Campbell, James
AU - Caws, Maxine
AU - Day, Jeremy
AU - de Jong, Menno D.
AU - van Vinh, Chau Nguyen
AU - van Doorn, H. Rogier
AU - Tinh, Hien Tran
AU - Farrar, Jeremy
AU - Schultsz, Constance
PY - 2012/5/25
Y1 - 2012/5/25
N2 - Background: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. Methods: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007- April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. Results: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. Conclusions: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.
AB - Background: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. Methods: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007- April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. Results: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. Conclusions: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.
U2 - 10.1371/journal.pone.0037825
DO - 10.1371/journal.pone.0037825
M3 - Article
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e37825
ER -
