Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Yanhui Lu; Connie Celum; Anna Wald; Jared M. Baeten; Frances Cowan; Sinead Delany-Moretlwe; Stewart E. Reid; James P. Hughes; Ellen Wilcox; Lawrence Corey; Craig W. Hendrix

doi:10.1128/aac.06160-11

Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Yanhui Lu
, Connie Celum
, Anna Wald
, Jared M. Baeten
, Frances Cowan
, Sinead Delany-Moretlwe
, Stewart E. Reid
, James P. Hughes
, Ellen Wilcox
, Lawrence Corey
, Craig W. Hendrix

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.

Original language	English
Pages (from-to)	2777-2779
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	5
DOIs	https://doi.org/10.1128/aac.06160-11
Publication status	Published - 1 May 2012
Externally published	Yes

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Lu, Y., Celum, C., Wald, A., Baeten, J. M., Cowan, F., Delany-Moretlwe, S., Reid, S. E., Hughes, J. P., Wilcox, E., Corey, L., & Hendrix, C. W. (2012). Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations. Antimicrobial Agents and Chemotherapy, 56(5), 2777-2779. https://doi.org/10.1128/aac.06160-11

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abstract = "Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54\% and 52\% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.",

author = "Yanhui Lu and Connie Celum and Anna Wald and Baeten, \{Jared M.\} and Frances Cowan and Sinead Delany-Moretlwe and Reid, \{Stewart E.\} and Hughes, \{James P.\} and Ellen Wilcox and Lawrence Corey and Hendrix, \{Craig W.\}",

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Lu, Y, Celum, C, Wald, A, Baeten, JM, Cowan, F, Delany-Moretlwe, S, Reid, SE, Hughes, JP, Wilcox, E, Corey, L & Hendrix, CW 2012, 'Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations', Antimicrobial Agents and Chemotherapy, vol. 56, no. 5, pp. 2777-2779. https://doi.org/10.1128/aac.06160-11

TY - JOUR

T1 - Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

AU - Lu, Yanhui

AU - Celum, Connie

AU - Wald, Anna

AU - Baeten, Jared M.

AU - Cowan, Frances

AU - Delany-Moretlwe, Sinead

AU - Reid, Stewart E.

AU - Hughes, James P.

AU - Wilcox, Ellen

AU - Corey, Lawrence

AU - Hendrix, Craig W.

PY - 2012/5/1

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N2 - Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.

AB - Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.

U2 - 10.1128/aac.06160-11

DO - 10.1128/aac.06160-11

M3 - Article

SN - 0066-4804

VL - 56

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Abstract

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