Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

Bárbara Molina-Moya; Raquel Villar-Hernández; Nelly Ciobanu; Beatriz Muriel-Moreno; Alicia Lacoma; Alexandru Codreanu; Irene Latorre; Daria Smalchuk; Cristina Prat-Aymerich; Valeriu Crudu; Nadia Kontogianni; Luis Cuevas; José Domínguez

doi:10.3389/ftubr.2023.1267221

Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

Bárbara Molina-Moya, Raquel Villar-Hernández, Nelly Ciobanu, Beatriz Muriel-Moreno, Alicia Lacoma, Alexandru Codreanu, Irene Latorre, Daria Smalchuk, Cristina Prat-Aymerich, Valeriu Crudu, Nadia Kontogianni, Luis Cuevas, José Domínguez

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease.

Methods: CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study.

Results: In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (p < 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's r < 0.6) were found between biomarkers.

Conclusion: The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.

Original language	English
Pages (from-to)	1267221
Journal	Frontiers in Tuberculosis
Early online date	29 Nov 2023
DOIs	https://doi.org/10.3389/ftubr.2023.1267221
Publication status	Published - 29 Nov 2023

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Cite this

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title = "Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis",

abstract = "Background: Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease. Methods: CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study. Results: In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (p < 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's r < 0.6) were found between biomarkers. Conclusion: The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.",

author = "B{\'a}rbara Molina-Moya and Raquel Villar-Hern{\'a}ndez and Nelly Ciobanu and Beatriz Muriel-Moreno and Alicia Lacoma and Alexandru Codreanu and Irene Latorre and Daria Smalchuk and Cristina Prat-Aymerich and Valeriu Crudu and Nadia Kontogianni and Luis Cuevas and Jos{\'e} Dom{\'i}nguez",

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day = "29",

doi = "10.3389/ftubr.2023.1267221",

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TY - JOUR

T1 - Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

AU - Molina-Moya, Bárbara

AU - Villar-Hernández, Raquel

AU - Ciobanu, Nelly

AU - Muriel-Moreno, Beatriz

AU - Lacoma, Alicia

AU - Codreanu, Alexandru

AU - Latorre, Irene

AU - Smalchuk, Daria

AU - Prat-Aymerich, Cristina

AU - Crudu, Valeriu

AU - Kontogianni, Nadia

AU - Cuevas, Luis

AU - Domínguez, José

PY - 2023/11/29

Y1 - 2023/11/29

N2 - Background: Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease. Methods: CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study. Results: In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (p < 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's r < 0.6) were found between biomarkers. Conclusion: The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.

AB - Background: Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease. Methods: CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study. Results: In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (p < 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's r < 0.6) were found between biomarkers. Conclusion: The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.

U2 - 10.3389/ftubr.2023.1267221

DO - 10.3389/ftubr.2023.1267221

M3 - Article

SN - 2813-7868

SP - 1267221

JO - Frontiers in Tuberculosis

JF - Frontiers in Tuberculosis

ER -

Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

Abstract

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