Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.

Victor S. Santos; Ricardo Q. Gurgel; Sandra M.M. Cavalcante; Andrew Kirby; Lilian P. Café; Maria J. Souto; Silvio S. Dolabella; Matheus R. de Assis; Tulio M. Fumian; Marize P. Miagostovich; Nigel A. Cunliffe; Luis Cuevas

doi:10.1016/j.jcv.2016.10.015

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.

Victor S. Santos, Ricardo Q. Gurgel, Sandra M.M. Cavalcante, Andrew Kirby, Lilian P. Café, Maria J. Souto, Silvio S. Dolabella, Matheus R. de Assis, Tulio M. Fumian, Marize P. Miagostovich, Nigel A. Cunliffe, Luis Cuevas

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Background

Gastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.

Objective

We describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.

Study design

A cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.

Results

In total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%).

Conclusion

Norovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	Journal of Clinical Virology
Volume	88
Early online date	29 Oct 2016
DOIs	https://doi.org/10.1016/j.jcv.2016.10.015
Publication status	Published - 1 Mar 2017

Keywords

Brazil
Children
Diarrhoea
Norovirus
Rotavirus vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jcv.2016.10.015

J Clin Viro 2017 Accepted Version acute norovirusAccepted author manuscript, 585 KBLicence: CC BY-NC-ND

Cite this

Santos, V. S., Gurgel, R. Q., Cavalcante, S. M. M., Kirby, A., Café, L. P., Souto, M. J., Dolabella, S. S., de Assis, M. R., Fumian, T. M., Miagostovich, M. P., Cunliffe, N. A., & Cuevas, L. (2017). Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil. Journal of Clinical Virology, 88, 33-38. https://doi.org/10.1016/j.jcv.2016.10.015

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title = "Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.",

abstract = "BackgroundGastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.ObjectiveWe describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.Study designA cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.ResultsIn total 280 (19.6\%) of 1432 samples were norovirus positive, including 204 (18.3\%) of 1113 samples collected during the first period and 76 (23.9\%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1\%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3\%), followed by GII.2 (6, 3.2\%) and GII.6 (5, 2.6\%).ConclusionNorovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.",

keywords = "Brazil, Children, Diarrhoea, Norovirus, Rotavirus vaccine",

author = "Santos, \{Victor S.\} and Gurgel, \{Ricardo Q.\} and Cavalcante, \{Sandra M.M.\} and Andrew Kirby and Caf{\'e}, \{Lilian P.\} and Souto, \{Maria J.\} and Dolabella, \{Silvio S.\} and \{de Assis\}, \{Matheus R.\} and Fumian, \{Tulio M.\} and Miagostovich, \{Marize P.\} and Cunliffe, \{Nigel A.\} and Luis Cuevas",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.jcv.2016.10.015",

language = "English",

volume = "88",

pages = "33--38",

journal = "Journal of Clinical Virology",

issn = "1386-6532",

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TY - JOUR

T1 - Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.

AU - Santos, Victor S.

AU - Gurgel, Ricardo Q.

AU - Cavalcante, Sandra M.M.

AU - Kirby, Andrew

AU - Café, Lilian P.

AU - Souto, Maria J.

AU - Dolabella, Silvio S.

AU - de Assis, Matheus R.

AU - Fumian, Tulio M.

AU - Miagostovich, Marize P.

AU - Cunliffe, Nigel A.

AU - Cuevas, Luis

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BackgroundGastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.ObjectiveWe describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.Study designA cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.ResultsIn total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%).ConclusionNorovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.

AB - BackgroundGastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.ObjectiveWe describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.Study designA cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.ResultsIn total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%).ConclusionNorovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.

KW - Brazil

KW - Children

KW - Diarrhoea

KW - Norovirus

KW - Rotavirus vaccine

U2 - 10.1016/j.jcv.2016.10.015

DO - 10.1016/j.jcv.2016.10.015

M3 - Article

SN - 1386-6532

VL - 88

SP - 33

EP - 38

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

ER -

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.

Abstract

Keywords

UN SDGs

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