TY - JOUR
T1 - A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.
AU - Duarte, Tonya Azevedo
AU - Nery, Joilda Silva
AU - Boechat, Neio
AU - Pereira, Susan Martins
AU - Simonsen, Vera
AU - Oliveira, Martha
AU - Gomes, Gabriela
AU - Penha-Gonçalves, Carlos
AU - Barreto, Mauricio Lima
AU - Barbosa, Theolis
PY - 2017/5/1
Y1 - 2017/5/1
N2 - IntroductionThe Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.MethodsEAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.ResultsThe EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently reported, with wide distribution of this particular clade described in Brazil. The distribution of other EAI spoligotyping patterns with broader worldwide distribution was restricted to the southeastern region of the country.ConclusionsEAI may be endemic at a low frequency in Brazil, with some clades indicating increased fitness with respect to this population.
AB - IntroductionThe Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.MethodsEAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.ResultsThe EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently reported, with wide distribution of this particular clade described in Brazil. The distribution of other EAI spoligotyping patterns with broader worldwide distribution was restricted to the southeastern region of the country.ConclusionsEAI may be endemic at a low frequency in Brazil, with some clades indicating increased fitness with respect to this population.
KW - Epidemiology
KW - Genotyping
KW - Mycobacterium tuberculosis
KW - Phylogeography
U2 - 10.1016/j.bjid.2017.01.005
DO - 10.1016/j.bjid.2017.01.005
M3 - Article
SN - 1413-8670
VL - 21
SP - 317
EP - 324
JO - Brazilian Journal of Infectious Diseases
JF - Brazilian Journal of Infectious Diseases
IS - 3
ER -
