A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

Rachel Bousfield; Miliya Thyl; Orng Samol; Loet Rithea; Soeng Sona; Hor Put Chhat; Sar Poda; Cartin E. Moore; Kheng Chheng; Varun Kumar; Nicholas P.J. Day; Christopher Parry

doi:10.1179/2046905515y.0000000009

A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

Rachel Bousfield, Miliya Thyl, Orng Samol, Loet Rithea, Soeng Sona, Hor Put Chhat, Sar Poda, Cartin E. Moore, Kheng Chheng, Varun Kumar, Nicholas P.J. Day, Christopher Parry

Research output: Contribution to journal › Article › peer-review

Abstract

Background:

Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.

Aims:

To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.

Methods:

In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.

Results:

In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.

Conclusions:

Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

Original language	English
Pages (from-to)	118-121
Number of pages	4
Journal	Paediatrics and International Child Health
Volume	36
Issue number	2
DOIs	https://doi.org/10.1179/2046905515y.0000000009
Publication status	Published - 27 Apr 2016

Keywords

Angkor Hospital for Children
Blood culture
Cambodia
Children
Enteric fever
Paediatric
Salmonella
Typhoid

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Bousfield, R., Thyl, M., Samol, O., Rithea, L., Sona, S., Chhat, H. P., Poda, S., Moore, C. E., Chheng, K., Kumar, V., Day, N. P. J., & Parry, C. (2016). A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever. Paediatrics and International Child Health, 36(2), 118-121. https://doi.org/10.1179/2046905515y.0000000009

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title = "A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever",

abstract = "Background: Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40\%.Aims: To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.Methods: In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.Results: In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70\% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.Conclusions: Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.",

keywords = "Angkor Hospital for Children, Blood culture, Cambodia, Children, Enteric fever, Paediatric, Salmonella, Typhoid",

author = "Rachel Bousfield and Miliya Thyl and Orng Samol and Loet Rithea and Soeng Sona and Chhat, \{Hor Put\} and Sar Poda and Moore, \{Cartin E.\} and Kheng Chheng and Varun Kumar and Day, \{Nicholas P.J.\} and Christopher Parry",

year = "2016",

month = apr,

day = "27",

doi = "10.1179/2046905515y.0000000009",

language = "English",

volume = "36",

pages = "118--121",

journal = "Paediatrics and International Child Health",

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publisher = "Taylor and Francis Ltd.",

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Bousfield, R, Thyl, M, Samol, O, Rithea, L, Sona, S, Chhat, HP, Poda, S, Moore, CE, Chheng, K, Kumar, V, Day, NPJ & Parry, C 2016, 'A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever', Paediatrics and International Child Health, vol. 36, no. 2, pp. 118-121. https://doi.org/10.1179/2046905515y.0000000009

TY - JOUR

T1 - A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

AU - Bousfield, Rachel

AU - Thyl, Miliya

AU - Samol, Orng

AU - Rithea, Loet

AU - Sona, Soeng

AU - Chhat, Hor Put

AU - Poda, Sar

AU - Moore, Cartin E.

AU - Chheng, Kheng

AU - Kumar, Varun

AU - Day, Nicholas P.J.

AU - Parry, Christopher

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Background: Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.Aims: To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.Methods: In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.Results: In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.Conclusions: Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

AB - Background: Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.Aims: To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.Methods: In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.Results: In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.Conclusions: Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

KW - Angkor Hospital for Children

KW - Blood culture

KW - Cambodia

KW - Children

KW - Enteric fever

KW - Paediatric

KW - Salmonella

KW - Typhoid

U2 - 10.1179/2046905515y.0000000009

DO - 10.1179/2046905515y.0000000009

M3 - Article

SN - 2046-9047

VL - 36

SP - 118

EP - 121

JO - Paediatrics and International Child Health

JF - Paediatrics and International Child Health

IS - 2

ER -

A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

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