A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

Paul N. Newton; Hung Thai Le; Quoc Tip Nguyen; Jennifer M. Short; Wirongrong Chierakul; Adul Rajanuwong; Punnee Pitisuttithum; Sanchai Chasombat; Benjaluck Phonrat; Wirach Maek-A-Nantawat; Reungsilp Teaunadi; David Lalloo; Nicholas J. White

doi:10.1086/342299

A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

Paul N. Newton
, Hung Thai Le
, Quoc Tip Nguyen
, Jennifer M. Short
, Wirongrong Chierakul
, Adul Rajanuwong
, Punnee Pitisuttithum
, Sanchai Chasombat
, Benjaluck Phonrat
, Wirach Maek-A-Nantawat
, Reungsilp Teaunadi
, David Lalloo
, Nicholas J. White

Clinical Sciences

Mahidol University
John Radcliffe Hospital
Institute of Malariology, Parasitology and Entomology
Sappasithiprasong Hospital
North East Regional Infectious Disease Hospital

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

Original language	English
Pages (from-to)	769-772
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	35
Issue number	6
DOIs	https://doi.org/10.1086/342299
Publication status	Published - 15 Sept 2002

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SDG 3 Good Health and Well-being

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10.1086/342299

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Newton, P. N., Le, H. T., Nguyen, Q. T., Short, J. M., Chierakul, W., Rajanuwong, A., Pitisuttithum, P., Chasombat, S., Phonrat, B., Maek-A-Nantawat, W., Teaunadi, R., Lalloo, D., & White, N. J. (2002). A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis. Clinical Infectious Diseases, 35(6), 769-772. https://doi.org/10.1086/342299

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title = "A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis",

abstract = "We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.",

author = "Newton, \{Paul N.\} and Le, \{Hung Thai\} and Nguyen, \{Quoc Tip\} and Short, \{Jennifer M.\} and Wirongrong Chierakul and Adul Rajanuwong and Punnee Pitisuttithum and Sanchai Chasombat and Benjaluck Phonrat and Wirach Maek-A-Nantawat and Reungsilp Teaunadi and David Lalloo and White, \{Nicholas J.\}",

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doi = "10.1086/342299",

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Newton, PN, Le, HT, Nguyen, QT, Short, JM, Chierakul, W, Rajanuwong, A, Pitisuttithum, P, Chasombat, S, Phonrat, B, Maek-A-Nantawat, W, Teaunadi, R, Lalloo, D & White, NJ 2002, 'A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis', Clinical Infectious Diseases, vol. 35, no. 6, pp. 769-772. https://doi.org/10.1086/342299

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T1 - A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

AU - Newton, Paul N.

AU - Le, Hung Thai

AU - Nguyen, Quoc Tip

AU - Short, Jennifer M.

AU - Chierakul, Wirongrong

AU - Rajanuwong, Adul

AU - Pitisuttithum, Punnee

AU - Chasombat, Sanchai

AU - Phonrat, Benjaluck

AU - Maek-A-Nantawat, Wirach

AU - Teaunadi, Reungsilp

AU - Lalloo, David

AU - White, Nicholas J.

PY - 2002/9/15

Y1 - 2002/9/15

N2 - We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

AB - We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

U2 - 10.1086/342299

DO - 10.1086/342299

M3 - Article

SN - 1058-4838

VL - 35

SP - 769

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 6

ER -

A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

Abstract

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