A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge

Helen Hill; Elena Mitsi; Elissavet Nikolaou; Annie Blizard; Sherin Pojar; Ashleigh Howard; Angela Hyder-Wright; Jack Devin; Jesus Reine Gutierrez; Ryan Robinson; Carla Solorzano; Simon P. Jochems; Tinashe Nyazika; Elisa Ramos-Sevillano; Caroline M. Weight; Christopher Myerscough; Daniella McLenaghan; Benjamin Morton; Emily Gibbons; Madi Farrar; Victoria Randles; Hassan Burhan; Tao Chen; Adam D. Shandling; Joe J. Campo; Robert S. Heyderman; Stephen Gordon; Jeremy S. Brown; Andrea Collins; Daniela Ferreira

doi:10.1164/rccm.202302-0222oc

A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge

Helen Hill
, Elena Mitsi
, Elissavet Nikolaou
, Annie Blizard
, Sherin Pojar
, Ashleigh Howard
, Angela Hyder-Wright
, Jack Devin
, Jesus Reine Gutierrez
, Ryan Robinson
, Carla Solorzano
, Simon P. Jochems
, Tinashe Nyazika
, Elisa Ramos-Sevillano
, Caroline M. Weight
, Christopher Myerscough
, Daniella McLenaghan
, Benjamin Morton
, Emily Gibbons
, Madi Farrar

Victoria Randles, Hassan Burhan, Tao Chen, Adam D. Shandling, Joe J. Campo, Robert S. Heyderman, Stephen Gordon, Jeremy S. Brown, Andrea Collins, Daniela Ferreira

University of Oxford
Liverpool School of Tropical Medicine
University of Liverpool
University College London
Antigen Discovery Inc (ADI)
Malawi-Liverpool-Wellcome Trust Clinical Research Programme

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Original language	English
Pages (from-to)	868-878
Number of pages	11
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	208
Issue number	8
Early online date	9 Aug 2023
DOIs	https://doi.org/10.1164/rccm.202302-0222oc
Publication status	Published - 9 Aug 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

attenuated strains
human challenge
nasal administration
Streptococcus pneumoniae

Access to Document

10.1164/rccm.202302-0222oc

Hill-et-al-2023-a-randomised-controlled-trial-of-nasal-immunisation-with-live-virulence-attenuated-streptococcusAccepted author manuscript, 2.13 MBLicence: CC BY

Cite this

Hill, H., Mitsi, E., Nikolaou, E., Blizard, A., Pojar, S., Howard, A., Hyder-Wright, A., Devin, J., Reine Gutierrez, J., Robinson, R., Solorzano, C., Jochems, S. P., Nyazika, T., Ramos-Sevillano, E., Weight, C. M., Myerscough, C., McLenaghan, D., Morton, B., Gibbons, E., ... Ferreira, D. (2023). A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge. American Journal of Respiratory and Critical Care Medicine, 208(8), 868-878. https://doi.org/10.1164/rccm.202302-0222oc

@article{3079d881ed3b42b88bbf413babad99e3,

title = "A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge",

keywords = "attenuated strains, human challenge, nasal administration, Streptococcus pneumoniae",

author = "Helen Hill and Elena Mitsi and Elissavet Nikolaou and Annie Blizard and Sherin Pojar and Ashleigh Howard and Angela Hyder-Wright and Jack Devin and \{Reine Gutierrez\}, Jesus and Ryan Robinson and Carla Solorzano and Jochems, \{Simon P.\} and Tinashe Nyazika and Elisa Ramos-Sevillano and Weight, \{Caroline M.\} and Christopher Myerscough and Daniella McLenaghan and Benjamin Morton and Emily Gibbons and Madi Farrar and Victoria Randles and Hassan Burhan and Tao Chen and Shandling, \{Adam D.\} and Campo, \{Joe J.\} and Heyderman, \{Robert S.\} and Stephen Gordon and Brown, \{Jeremy S.\} and Andrea Collins and Daniela Ferreira",

year = "2023",

month = aug,

day = "9",

doi = "10.1164/rccm.202302-0222oc",

language = "English",

volume = "208",

pages = "868--878",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "8",

}

Hill, H, Mitsi, E, Nikolaou, E, Blizard, A, Pojar, S, Howard, A, Hyder-Wright, A, Devin, J, Reine Gutierrez, J, Robinson, R, Solorzano, C, Jochems, SP, Nyazika, T, Ramos-Sevillano, E, Weight, CM, Myerscough, C, McLenaghan, D, Morton, B, Gibbons, E, Farrar, M, Randles, V, Burhan, H, Chen, T, Shandling, AD, Campo, JJ, Heyderman, RS, Gordon, S, Brown, JS, Collins, A & Ferreira, D 2023, 'A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge', American Journal of Respiratory and Critical Care Medicine, vol. 208, no. 8, pp. 868-878. https://doi.org/10.1164/rccm.202302-0222oc

A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge. / Hill, Helen; Mitsi, Elena; Nikolaou, Elissavet et al.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 208, No. 8, 09.08.2023, p. 868-878.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge

AU - Hill, Helen

AU - Mitsi, Elena

AU - Nikolaou, Elissavet

AU - Blizard, Annie

AU - Pojar, Sherin

AU - Howard, Ashleigh

AU - Hyder-Wright, Angela

AU - Devin, Jack

AU - Reine Gutierrez, Jesus

AU - Robinson, Ryan

AU - Solorzano, Carla

AU - Jochems, Simon P.

AU - Nyazika, Tinashe

AU - Ramos-Sevillano, Elisa

AU - Weight, Caroline M.

AU - Myerscough, Christopher

AU - McLenaghan, Daniella

AU - Morton, Benjamin

AU - Gibbons, Emily

AU - Farrar, Madi

AU - Randles, Victoria

AU - Burhan, Hassan

AU - Chen, Tao

AU - Shandling, Adam D.

AU - Campo, Joe J.

AU - Heyderman, Robert S.

AU - Gordon, Stephen

AU - Brown, Jeremy S.

AU - Collins, Andrea

AU - Ferreira, Daniela

PY - 2023/8/9

Y1 - 2023/8/9

KW - attenuated strains

KW - human challenge

KW - nasal administration

KW - Streptococcus pneumoniae

U2 - 10.1164/rccm.202302-0222oc

DO - 10.1164/rccm.202302-0222oc

M3 - Article

SN - 1073-449X

VL - 208

SP - 868

EP - 878

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 8

ER -