A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle

Paul M. O'Neill; Steve Ward

doi:10.1002/anie.201507264

A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle

Paul M. O'Neill, Steve Ward

Tropical Disease Biology

University of Liverpool

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Putting a stop to malaria: Phenotypic screening against malaria parasites, hit identification, and efficient lead optimization have delivered the preclinical candidate antimalarial DDD107498. This molecule is distinctive in that it has potential for use as a single-dose cure for malaria and shows a unique broad spectrum of activity against the liver, blood, and mosquito stages of the parasite life cycle.

Original language	English
Pages (from-to)	13504-13506
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	46
DOIs	https://doi.org/10.1002/anie.201507264
Publication status	Published - 2 Nov 2015

Keywords

antimalarials
drug discovery
inhibitors
lead-optimization
medicinal chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201507264

Cite this

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KW - drug discovery

KW - inhibitors

KW - lead-optimization

KW - medicinal chemistry

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M3 - Article

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A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle

Abstract

Keywords

UN SDGs

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