A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease

G. S. Cooke; K. Tosh; P. A. Ramaley; P. Kaleebu; J. Zhuang; J. S. Nakiyingi; C. Watera; C.F. Gilks; Neil French; J. A. G. Whitworth; A. V. S. Hill

doi:10.1086/505875

A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease

G. S. Cooke, K. Tosh, P. A. Ramaley, P. Kaleebu, J. Zhuang, J. S. Nakiyingi, C. Watera, C.F. Gilks, Neil French, J. A. G. Whitworth, A. V. S. Hill

Liverpool School of Tropical Medicine

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

Original language	English
Pages (from-to)	666-669
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	194
Issue number	5
DOIs	https://doi.org/10.1086/505875
Publication status	Published - 1 Sept 2006

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Cooke, G. S., Tosh, K., Ramaley, P. A., Kaleebu, P., Zhuang, J., Nakiyingi, J. S., Watera, C., Gilks, C. F., French, N., Whitworth, J. A. G., & Hill, A. V. S. (2006). A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease. Journal of Infectious Diseases, 194(5), 666-669. https://doi.org/10.1086/505875

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title = "A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease",

abstract = "We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95\% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.",

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Cooke, GS, Tosh, K, Ramaley, PA, Kaleebu, P, Zhuang, J, Nakiyingi, JS, Watera, C, Gilks, CF, French, N, Whitworth, JAG & Hill, AVS 2006, 'A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease', Journal of Infectious Diseases, vol. 194, no. 5, pp. 666-669. https://doi.org/10.1086/505875

TY - JOUR

T1 - A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease

AU - Cooke, G. S.

AU - Tosh, K.

AU - Ramaley, P. A.

AU - Kaleebu, P.

AU - Zhuang, J.

AU - Nakiyingi, J. S.

AU - Watera, C.

AU - Gilks, C.F.

AU - French, Neil

AU - Whitworth, J. A. G.

AU - Hill, A. V. S.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

AB - We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

U2 - 10.1086/505875

DO - 10.1086/505875

M3 - Article

SN - 0022-1899

VL - 194

SP - 666

EP - 669

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease

Abstract

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