A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Neil E. Jenkins; Tabitha W. Mwangi; Moses Kortok; Kevin Marsh; Alister Craig; Thomas H. Williams

doi:10.1086/498156

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Neil E. Jenkins, Tabitha W. Mwangi, Moses Kortok, Kevin Marsh, Alister Craig, Thomas H. Williams

Biological Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Original language	English
Pages (from-to)	1817-1819
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	41
Issue number	12
DOIs	https://doi.org/10.1086/498156
Publication status	Published - 15 Dec 2005

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10.1086/498156

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title = "A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children",

abstract = "An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.",

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AU - Jenkins, Neil E.

AU - Mwangi, Tabitha W.

AU - Kortok, Moses

AU - Marsh, Kevin

AU - Craig, Alister

AU - Williams, Thomas H.

PY - 2005/12/15

Y1 - 2005/12/15

N2 - An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

AB - An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

U2 - 10.1086/498156

DO - 10.1086/498156

M3 - Article

SN - 1058-4838

VL - 41

SP - 1817

EP - 1819

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Abstract

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