A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Neil E. Jenkins; Tabitha W. Mwangi; Moses Kortok; Kevin Marsh; Alister Craig; Thomas H. Williams

doi:10.1086/498156

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Neil E. Jenkins
, Tabitha W. Mwangi
, Moses Kortok
, Kevin Marsh
, Alister Craig
, Thomas H. Williams

Biological Sciences

Wellcome Trust Research Laboratories Nairobi
Liverpool School of Tropical Medicine
John Radcliffe Hospital

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Original language	English
Pages (from-to)	1817-1819
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	41
Issue number	12
DOIs	https://doi.org/10.1086/498156
Publication status	Published - 15 Dec 2005

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SDG 3 Good Health and Well-being

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10.1086/498156

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abstract = "An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.",

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AU - Kortok, Moses

AU - Marsh, Kevin

AU - Craig, Alister

AU - Williams, Thomas H.

PY - 2005/12/15

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N2 - An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

AB - An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

U2 - 10.1086/498156

DO - 10.1086/498156

M3 - Article

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VL - 41

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Abstract

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