A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

Alexei Yu Kostygov; Danyil Grybchuk; Senne Heeren; Evgeny S. Gerasimov; Donnamae Klocek; Aditya Reddy; Jovana Sádlová; Lenka Pacáková; Alain Kohl; František Stejskal; Petr Volf; Jean Claude Dujardin; Vyacheslav Yurchenko

doi:10.1371/journal.pntd.0012767

A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

Alexei Yu Kostygov, Danyil Grybchuk, Senne Heeren, Evgeny S. Gerasimov, Donnamae Klocek, Aditya Reddy, Jovana Sádlová, Lenka Pacáková, Alain Kohl, František Stejskal, Petr Volf, Jean Claude Dujardin, Vyacheslav Yurchenko

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.

Original language	English
Article number	e0012767
Pages (from-to)	e0012767
Journal	PLoS Neglected Tropical Diseases
Volume	18
Issue number	12
Early online date	27 Dec 2024
DOIs	https://doi.org/10.1371/journal.pntd.0012767
Publication status	Published - 27 Dec 2024

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Kostygov, A. Y., Grybchuk, D., Heeren, S., Gerasimov, E. S., Klocek, D., Reddy, A., Sádlová, J., Pacáková, L., Kohl, A., Stejskal, F., Volf, P., Dujardin, J. C., & Yurchenko, V. (2024). A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. PLoS Neglected Tropical Diseases, 18(12), e0012767. Article e0012767. https://doi.org/10.1371/journal.pntd.0012767

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title = "A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus",

abstract = "Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.",

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AU - Gerasimov, Evgeny S.

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AU - Reddy, Aditya

AU - Sádlová, Jovana

AU - Pacáková, Lenka

AU - Kohl, Alain

AU - Stejskal, František

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AU - Yurchenko, Vyacheslav

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AB - Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.

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A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

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